| Vegan diet-based lifestyle program rapidly lowers homocysteine levels. | |
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MedLine Citation:
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PMID: 10684746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plasma homocysteine levels have been directly associated with cardiac disease risk. Current research raises concerns as to whether comprehensive lifestyle approaches including a plant-based diet may interact with other known modulators of homocysteine levels. METHODS: We report our observations of homocysteine levels in 40 self-selected subjects who participated in a vegan diet-based lifestyle program. Each subject attended a residential lifestyle change program at the Lifestyle Center of America in Sulphur, Oklahoma and had fasting plasma total homocysteine measured on enrollment and then after 1 week of lifestyle intervention. The intervention included a vegan diet, moderate physical exercise, stress management and spirituality enhancement sessions, group support, and exclusion of tobacco, alcohol, and caffeine. B vitamin supplements known to reduce blood homocysteine levels were not provided. RESULTS: Subjects' mean homocysteine levels fell 13%: from 8.66 micromol/L (SD 2.7 micromol/L) to 7.53 micromol/L (SD 2.12 micromol/L; P < 0.0001). Subgroup analysis showed that homocysteine decreased across a range of demographic and diagnostic categories. Conclusions. Our results suggest that broad-based lifestyle interventions favorably impact homocysteine levels. Furthermore, analysis of Lifestyle Center of America program components suggests that other factors in addition to B vitamin intake may be involved in the observed homocysteine lowering. |
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Authors:
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D J DeRose; Z L Charles-Marcel; J M Jamison; J E Muscat; M A Braman; G D McLane; J Keith Mullen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Preventive medicine Volume: 30 ISSN: 0091-7435 ISO Abbreviation: Prev Med Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-06-14 Completed Date: 2000-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0322116 Medline TA: Prev Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 225-33 Citation Subset: IM |
Affiliation:
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Lifestyle Center of America in Sulphur, Oklahoma 73086, USA. drderose@brightok.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cardiovascular Diseases / blood, prevention & control* Diet Diet, Vegetarian* Female Homocysteine / blood* Humans Life Style Male Middle Aged Risk Factors |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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