Document Detail


Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock.
MedLine Citation:
PMID:  17068124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Organisms use the daily cycles of light and darkness to synchronize their internal circadian clocks with the environment. Because they optimize physiological processes and behavior, properly synchronized circadian clocks are thought to be important for the overall fitness. In Drosophila melanogaster, the circadian clock is synchronized with the natural environment by light-dependent degradation of the clock protein Timeless, mediated by the blue-light photoreceptor Cryptochrome (Cry). Here we report identification of a genetic variant, Veela, which severely disrupts this process, because these genetically altered flies maintain behavioral and molecular rhythmicity under constant-light conditions that usually stop the clock. We show that the Veela strain carries a natural timeless allele (ls-tim), which encodes a less-light-sensitive form of Timeless in combination with a mutant variant of the F-box protein Jetlag. However, neither the ls-tim nor the jetlag genetic variant alone is sufficient to disrupt light input into the central pacemaker. We show a strong interaction between Veela and cryptochrome genetic variants, demonstrating that the Jetlag, Timeless, and Cry proteins function in the same pathway. Veela also reveals a function for the two natural variants of timeless, which differ in their sensitivity to light. In combination with the complex array of retinal and extraretinal photoreceptors known to signal light to the pacemaker, this previously undescribed molecular component of photic sensitivity mediated by the two Timeless proteins reveals that an unexpectedly rich complexity underlies modulation of this process.
Authors:
Nicolai Peschel; Shobi Veleri; Ralf Stanewsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-26
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  103     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-19     Completed Date:  2007-01-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17313-8     Citation Subset:  IM    
Affiliation:
Institute of Zoology, University of Regensburg, Universitätsstrasse 31, 93040 Regensburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Amino Acid Sequence
Animals
Animals, Genetically Modified
Circadian Rhythm / physiology*
Cryptochromes
Drosophila Proteins / chemistry,  genetics,  metabolism*
Drosophila melanogaster / genetics,  metabolism*
F-Box Proteins / chemistry,  genetics,  metabolism
Flavoproteins / genetics,  metabolism*
Light*
Molecular Sequence Data
Motor Activity
Mutation / genetics
Neuroglia / metabolism
Neurons / metabolism
Polymorphism, Genetic / genetics
Renin / metabolism
Sequence Alignment
Signal Transduction*
Chemical
Reg. No./Substance:
0/Cryptochromes; 0/Drosophila Proteins; 0/F-Box Proteins; 0/Flavoproteins; 0/JETLAG protein, Drosophila; 0/timeless protein, Drosophila; EC 3.4.23.15/Renin
Comments/Corrections
Comment In:
Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17583-4   [PMID:  17101961 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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