Document Detail


Vecuronium bromide and succinylcholine procedures in medial relaxation. A comparison of electromyography and clinical findings
MedLine Citation:
PMID:  2569848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical and electromyographic effects of either succinylcholine (Suc) or vecuronium bromide (VEC) were compared during induction and maintenance of neuromuscular blockade for pelvic laparoscopy. METHODS: Forty ASA class I and II patients (pat.) were studied under general anesthesia with thiopental, enflurane, and nitrous oxide. Group VEC-pat. (n = 20) received 0.015 mg/kg body wt. VEC as priming and 5 min later 0.085 mg/kg as intubation doses. Repetitive doses of 0.01 mg/kg were injected to maintain twitch depression (T1%) less than or equal to 15%. Neuromuscular block was reversed with atropine and pyridostigmine (0.01 resp. 0.1 mg/kg). In group Suc-pat. relaxation was induced with 1.5 mg/kg Suc 5 min after pretreatment with 2 mg alcuronium. Relaxation (10% less than or equal to T1% less than or equal to 15%) was prolonged using a Suc infusion. Neuromuscular blockade was assessed electromyographically (Relaxograph, Datex) using train-of-four (TOF) stimulation (2 Hz for 2 s). Intubation conditions were scored according to Fahey et al. RESULTS: Pretreatment with 0.015 mg/kg VEC compared to 2 mg alcuronium led to a more pronounced decline in T1% and TOF-ratio (P less than 0.001). The time interval between injection of the intubation dose and complete relaxation (T1% less than or equal to 5%) was shorter in group Suc- than in VEC-pat. (P less than 0.001). Suc provides better intubation conditions than VEC (P less than 0.05). Recovery from muscle relaxation was faster in Suc- than in VEC-pat. (P less than 0.001). During Suc infusion in 8 patients a phase-II block (TOF ratio less than or equal to 30%) was observed. DISCUSSION: Postoperative problems are often related to an unrecognized after effects of relaxants. Suc infusion leads to a remarkable number of phase-II blocks, whereas VEC can be antagonized promptly.
Authors:
K H Leyser; D Konietzke; H J Hennes
Publication Detail:
Type:  Clinical Trial; Comparative Study; English Abstract; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Der Anaesthesist     Volume:  38     ISSN:  0003-2417     ISO Abbreviation:  Anaesthesist     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-08     Completed Date:  1989-09-08     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370525     Medline TA:  Anaesthesist     Country:  GERMANY, WEST    
Other Details:
Languages:  ger     Pagination:  288-93     Citation Subset:  IM    
Affiliation:
Klinik f?r Anaesthesiologie der Johannes-Gutenberg-Universit?t Mainz.
Vernacular Title:
Vecuroniumbromid- und Succinylcholinverfahren zur mittelangen Relaxation. Ein Vergleich anhand elektromyographischer und klinischer Befunde.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia*
Electromyography
Humans
Laparoscopy
Muscle Relaxation / drug effects
Pelvis
Postoperative Period
Preanesthetic Medication
Succinylcholine*
Vecuronium Bromide*
Chemical
Reg. No./Substance:
306-40-1/Succinylcholine; 50700-72-6/Vecuronium Bromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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