Document Detail


Vastus lateralis/vastus medialis cross-sectional area ratio impacts presence and degree of knee joint abnormalities and cartilage T2 determined with 3T MRI - an analysis from the incidence cohort of the Osteoarthritis Initiative.
MedLine Citation:
PMID:  21044692     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the role of vastus lateralis/vastus medialis cross-sectional area CSA ratio (VL/VM CSA ratio) in preclinical knee osteoarthritis (OA) using magnetic resonance imaging (MRI)-based cartilage T2 mapping technique and morphological analysis at 3.0T in non-symptomatic, middle-aged subjects.
MATERIAL AND METHODS: 174 non-symptomatic individuals aged 45-55 years with OA risk factors were selected from the Osteoarthritis Initiative (OAI) incidence cohort. OA-related knee abnormalities were analyzed using the whole-organ magnetic resonance imaging score (WORMS). Knee cartilage T2 maps were generated using sagittal 2D multi-echo spin-echo images of the right knee. CSA of thigh muscles was measured using axial T1W images of the right mid thigh. Spline-based segmentation of cartilage and muscles was performed on a SUN/SPARC workstation. Muscle measurements were normalized to body size using body surface area (BSA). Statistical significance was determined using Student's t-test, Pearson correlation test, and multiple regression models. To correct for multiple testing, Bonferroni adjustments were applied across all tests within each of the primary results tables (Tables III-VII).
RESULTS: Higher T2 values were associated with increased prevalence and severity of cartilage degeneration. In our study, male and female subjects with higher VL/VM CSA ratio demonstrated significantly lower mean cartilage T2 values (all compartments combined) (mean 44.10 vs 45.17, P=0.0017), and significantly lower WORMS scores (mean 14.12 vs 18.68, P=0.0316). Regression analyses of combined mean cartilage T2 using VL/VM CSA ratio as a continuous predictor showed a significant curvilinear relationship between these two variables (P=0.0082).
CONCLUSION: Our results suggested that higher VL/VM CSA ratio is associated with lower T2 values and decreased presence and severity of OA-related morphological changes. Additional studies will be needed to determine causality.
Authors:
J Pan; C Stehling; C Muller-Hocker; B J Schwaiger; J Lynch; C E McCulloch; M C Nevitt; T M Link
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-31
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  19     ISSN:  1522-9653     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-27     Completed Date:  2011-02-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA. judong.pan@radiology.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Cartilage, Articular / pathology*
Cohort Studies
Female
Humans
Incidence
Knee Joint / pathology*
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Osteoarthritis, Knee / epidemiology,  physiopathology*
Prevalence
Quadriceps Muscle / anatomy & histology*
Reproducibility of Results
Sex Factors
Grant Support
ID/Acronym/Agency:
N01 AR022258/AR/NIAMS NIH HHS; N01-AR-2-2258/AR/NIAMS NIH HHS; N01-AR-2-2259/AR/NIAMS NIH HHS; N01-AR-2-2260/AR/NIAMS NIH HHS; N01-AR-2-2261/AR/NIAMS NIH HHS; N01-AR-2-2262/AR/NIAMS NIH HHS
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