| Vastus lateralis/vastus medialis cross-sectional area ratio impacts presence and degree of knee joint abnormalities and cartilage T2 determined with 3T MRI - an analysis from the incidence cohort of the Osteoarthritis Initiative. | |
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MedLine Citation:
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PMID: 21044692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the role of vastus lateralis/vastus medialis cross-sectional area CSA ratio (VL/VM CSA ratio) in preclinical knee osteoarthritis (OA) using magnetic resonance imaging (MRI)-based cartilage T2 mapping technique and morphological analysis at 3.0T in non-symptomatic, middle-aged subjects. MATERIAL AND METHODS: 174 non-symptomatic individuals aged 45-55 years with OA risk factors were selected from the Osteoarthritis Initiative (OAI) incidence cohort. OA-related knee abnormalities were analyzed using the whole-organ magnetic resonance imaging score (WORMS). Knee cartilage T2 maps were generated using sagittal 2D multi-echo spin-echo images of the right knee. CSA of thigh muscles was measured using axial T1W images of the right mid thigh. Spline-based segmentation of cartilage and muscles was performed on a SUN/SPARC workstation. Muscle measurements were normalized to body size using body surface area (BSA). Statistical significance was determined using Student's t-test, Pearson correlation test, and multiple regression models. To correct for multiple testing, Bonferroni adjustments were applied across all tests within each of the primary results tables (Tables III-VII). RESULTS: Higher T2 values were associated with increased prevalence and severity of cartilage degeneration. In our study, male and female subjects with higher VL/VM CSA ratio demonstrated significantly lower mean cartilage T2 values (all compartments combined) (mean 44.10 vs 45.17, P=0.0017), and significantly lower WORMS scores (mean 14.12 vs 18.68, P=0.0316). Regression analyses of combined mean cartilage T2 using VL/VM CSA ratio as a continuous predictor showed a significant curvilinear relationship between these two variables (P=0.0082). CONCLUSION: Our results suggested that higher VL/VM CSA ratio is associated with lower T2 values and decreased presence and severity of OA-related morphological changes. Additional studies will be needed to determine causality. |
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Authors:
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J Pan; C Stehling; C Muller-Hocker; B J Schwaiger; J Lynch; C E McCulloch; M C Nevitt; T M Link |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-31 |
Journal Detail:
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Title: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Volume: 19 ISSN: 1522-9653 ISO Abbreviation: Osteoarthr. Cartil. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-27 Completed Date: 2011-02-24 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 9305697 Medline TA: Osteoarthritis Cartilage Country: England |
Other Details:
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Languages: eng Pagination: 65-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA. judong.pan@radiology.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cartilage, Articular
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pathology* Cohort Studies Female Humans Incidence Knee Joint / pathology* Magnetic Resonance Imaging / methods* Male Middle Aged Osteoarthritis, Knee / epidemiology, physiopathology* Prevalence Quadriceps Muscle / anatomy & histology* Reproducibility of Results Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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N01 AR022258/AR/NIAMS NIH HHS; N01-AR-2-2258/AR/NIAMS NIH HHS; N01-AR-2-2259/AR/NIAMS NIH HHS; N01-AR-2-2260/AR/NIAMS NIH HHS; N01-AR-2-2261/AR/NIAMS NIH HHS; N01-AR-2-2262/AR/NIAMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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