Document Detail

Vasotocin and hydrin 2 (vasotocinyl-Gly) in the African toad Bufo regularis: study under various environmental conditions.
MedLine Citation:
PMID:  8097151     Owner:  NLM     Status:  MEDLINE    
1. The neurohypophysial osmoregulatory hormones of the African toad Bufo regularis, a species adapted to estivate under dry and hot conditions, have been investigated. Vasotocin and hydrin 2 (vasotocinyl-Gly) have been identified by their retention times in high-pressure reverse-phase liquid chromatography and coelution with synthetic peptides, their pharmacological properties (vasotocin) and microsequencing. 2. Vasotocin-associated neurophysin (MSEL-neurophysin type) has been characterized by its N-terminal amino acid sequence. 3. In toads subjected to dehydration by evaporation (20% weight loss) or to osmotic stress by immersion in 2% NaCl for 3 hr (6% weight loss), the molar ratio hydrin 2/vasotocin (about 2:1) remained similar to the one observed in control animals. 4. In toads exposed to saline solution, there was a large decrease (roughly 30%) in the amounts of both hormones in the neuro-hypophysis. Environmental conditions for distinct secretions of vasotocin and hydrin 2 remain to be found.
J Chauvet; Y Ouedraogo; G Michel; R Acher
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Comparative physiology     Volume:  104     ISSN:  -     ISO Abbreviation:  Comp. Biochem. Physiol. Comp. Physiol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-18     Completed Date:  1993-05-18     Revised Date:  2006-11-28    
Medline Journal Info:
Nlm Unique ID:  9441449     Medline TA:  Comp Biochem Physiol Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  497-502     Citation Subset:  IM    
Laboratory of Biological Chemistry, University of Paris, France.
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MeSH Terms
Amino Acid Sequence
Arginine Vasopressin / metabolism
Biological Assay
Chromatography, High Pressure Liquid
Dehydration / physiopathology
Molecular Sequence Data
Neurophysins / metabolism
Osmolar Concentration
Pituitary Gland, Posterior / metabolism*
Protein Precursors / metabolism
Spectrophotometry, Ultraviolet
Vasotocin / analogs & derivatives*,  metabolism
Reg. No./Substance:
0/Neurophysins; 0/Protein Precursors; 113-79-1/Arginine Vasopressin; 122842-55-1/hydrin 2; 50-56-6/Oxytocin; 9034-50-8/Vasotocin

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