Document Detail


Vasospasm in monkeys resolves because of loss of and encasement of subarachnoid blood clot.
MedLine Citation:
PMID:  11486119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: We studied in monkeys why vasospasm resolves after subarachnoid hemorrhage (SAH). METHODS: Monkeys underwent angiography and right (n=17) or bilateral (n=8) SAH. Animals with bilateral SAH underwent angiography 1, 3, 5, and 7 days later. Animals with right SAH underwent angiography 7 days later. The clot was then not removed (n=5), removed and replaced with fresh clot (n=7), or removed and not replaced (n=5). At the same time on day 7, the removed clot (n=12) or fresh clot (n=5) was placed on the left side. Angiography was repeated every 2 days until day 14. RESULTS: SAH caused significant vasospasm on day 7 that resolved by day 14. Removal of clot on day 7 resulted in more rapid resolution of vasospasm. Placement of fresh clot onto arteries that had already been exposed to clot for 7 days produced vasospasm that persisted without resolving for an additional 7 days. Placement of 7-day-old clot from the right onto previously unexposed left arteries or of clot from blood removed from an animal 7 days after SAH caused significantly more rapid onset of vasospasm compared with de novo vasospasm. Microscopic examination of the clots showed they were surrounded by macrophages 7 days after SAH. Arterial compliance and contractility were reduced in relation to duration of the exposure of arteries to clot. CONCLUSIONS: Vasospasm resolves because of loss of subarachnoid blood clot. We hypothesize that reduced spasmogen release from the clot contributes to resolution of vasospasm. There was no response in the cerebral arteries that rendered them less responsive to the subarachnoid clot.
Authors:
Z D Zhang; B Yamini; T Komuro; S Ono; L Johns; L S Marton; B Weir; R L Macdonald
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  32     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-03     Completed Date:  2001-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1868-74     Citation Subset:  IM    
Affiliation:
Section of Neurosurgery, Department of Surgery, Pritzker School of Medicine, University of Chicago Medical Center, Chicago, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Basilar Artery / drug effects
Cerebral Angiography
Disease Models, Animal
Disease Progression
Hemoglobins / analysis
Macaca fascicularis
Middle Cerebral Artery / drug effects,  physiopathology,  radiography
Potassium Chloride / pharmacology
Remission, Spontaneous
Subarachnoid Hemorrhage / complications,  pathology,  physiopathology*
Subarachnoid Space / pathology
Thrombosis / complications,  pathology,  physiopathology*
Vascular Patency
Vasoconstriction / drug effects
Vasospasm, Intracranial / etiology,  pathology,  physiopathology*
Chemical
Reg. No./Substance:
0/Hemoglobins; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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