Document Detail


Vasoreactivity before and after handgrip training in chronic heart failure patients.
MedLine Citation:
PMID:  23010159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODS: CHF (n = 10; age = 62 ± 8 yrs) and CON (n = 10; age = 55 ± 5 yrs) subjects completed 4 weeks of bilateral handgrip training (20 min; 60% of maximal handgrip strength; 15 grips*min(-1); 4 days*week(-1)). Handgrip strength was measured using a hand dynamometer. Brachial artery flow-mediated dilation (BAFMD) and cold pressor test (CPT) responses were determined using ultrasonography prior to training, at the end of 4 weeks of training and following 4 weeks of detraining. Absolute (mm) BAFMD and CPT responses were combined to yield a vascular operating range (VOR).
RESULTS: Baseline BAFMD was higher in CON (CHF: 2.98 ± 1.49%; CON: 6.21 ± 1.21%; p = 0.01), while CPT responses were higher in CHF (CHF: 3.38 ± 0.83%; CON: 2.46 ± 0.62%; p = 0.05). Baseline VOR tended to be greater in the CON subjects (CHF: 0.28 ± 0.05 mm; CON: 0.32 ± 0.12 mm; p = 0.06). Training increased handgrip strength (∼5%; p < 0.05, for both groups), BAFMD (CHF: 2.98 ± 1.49% to 3.75 ± 1.56%; CON: 6.21 ± 1.21% - 8.02 ± 1.75%; p = 0.01) and VOR (CHF: 0.28 ± 0.05 mm - 0.3 ± 0.09 mm; CON: 0.32 ± 0.12 mm - 0.42 ± 0.11 mm; p = 0.01). There were no significant changes in CPT responses. All markers approached pre-training values following detraining.
CONCLUSION: Handgrip exercise increases strength, BAFMD and VOR in both CHF and CON subjects. These improvements are transient and return to pre-training values after removal of the training stimulus.
Authors:
Daniel P Credeur; Nithya Mariappan; Joseph Francis; David Thomas; Denzil Moraes; Michael A Welsch
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Publication Detail:
Type:  Journal Article     Date:  2012-09-16
Journal Detail:
Title:  Atherosclerosis     Volume:  225     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-04-11     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  154-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
University of Missouri, Columbia, MO, Baton Rouge, LA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brachial Artery / physiology*,  ultrasonography
Exercise / physiology
Forearm / blood supply
Hand Strength / physiology
Heart Failure / rehabilitation*
Humans
Middle Aged
Regional Blood Flow / physiology
Resistance Training*
Vasoconstriction / physiology*
Vasodilation / physiology*
Grant Support
ID/Acronym/Agency:
RC1 AG035822/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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