| Vasoreactivity of Fluosol perfluorocarbon emulsion vs. Earl's balanced salt/albumin perfusates in the isolated perfused rat lung. | |
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MedLine Citation:
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PMID: 7493066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compare the vasoreactive responses of Fluosol perfluorocarbon emulsion versus Earl's balanced salt+albumin solution as perfusates in an isolated perfused rat lung. Comparisons were made with three separate vasoconstrictive stimuli: norepinephrine, and prostaglandin F2 alpha dose-response analysis, and generation of hypoxic pulmonary vasoconstriction. The hypoxia experiments were also performed with N-nitro-arginine added to the perfusates to block production of endogenous nitric oxide prior to the application of hypoxic ventilation challenge. The vasoconstrictive effects of norepinephrine, PGF2 alpha and hypoxia were significantly depressed in the perfluorocarbon perfused versus salt/albumin solution perfused lungs. With the addition of NNA to the perfusates, hypoxic pulmonary vasoconstriction is enhanced in both Earl's/albumin perfused as well as in the fluorocarbon perfused lungs. We can conclude that the pulmonary vasoconstrictive effects of norepinephrine, PGF2 alpha, and hypoxia are depressed in perfluorocarbon emulsion perfused, compared to salt-albumin solution perfused lungs. It is possible that perfluorocarbon emulsions interfere with normal endothelial function. As such, these compounds may be useful in examination of normal and abnormal endothelial function in various research applications. |
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Authors:
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C J Mullett; M J Polak |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 23 ISSN: 1073-1199 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 1995 |
Date Detail:
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Created Date: 1996-01-11 Completed Date: 1996-01-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 449-57 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, West Virginia University School of Medicine, Morgantown 26506-9214, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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pharmacology* Animals Blood Substitutes / pharmacology* Fluorocarbons / pharmacology* Lung / blood supply, drug effects* Male Perfusion Rats Rats, Sprague-Dawley Solutions Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Blood Substitutes; 0/Fluorocarbons; 0/Solutions; 0/Vasoconstrictor Agents; 83271-20-9/fluosol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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