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Vasoprotection by dietary supplements and exercise: role of TNFα signaling.
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PMID:  22110483     Owner:  NLM     Status:  MEDLINE    
Vascular dysfunction contributes to the pathogenesis of various cardiovascular diseases. Dietary supplements, including fish oil, dietary fibers, and various natural products, and exercise training exert vasoprotective effects. However, the mechanisms underlying the vasoprotective benefits of dietary supplements and physical activity demand extensive investigation. Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNFα) plays a pivotal role in the dysregulation of macrovascular and microvascular function. TNFα induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through multiple signaling pathways involving NFκB, Sp1, activator protein 1, JNK, p38, STAT3, and so forth. Dietary supplements and exercise training decrease TNFα production and ameliorate TNFα-mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements and physical exercise on TNFα production and TNFα signaling may contribute to their vasoprotective properties.
Hanrui Zhang; Cuihua Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-11-01
Journal Detail:
Title:  Experimental diabetes research     Volume:  2012     ISSN:  1687-5303     ISO Abbreviation:  Exp Diabetes Res     Publication Date:  2012  
Date Detail:
Created Date:  2011-11-23     Completed Date:  2012-03-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101274844     Medline TA:  Exp Diabetes Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  972679     Citation Subset:  IM    
Division of Cardiovascular Medicine, Departments of Internal Medicine, Medical Pharmacology and Physiology, and Nutritional Sciences, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA.
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MeSH Terms
Diabetes Mellitus, Type 2 / complications
Dietary Fiber / administration & dosage
Dietary Supplements*
Fish Oils / administration & dosage
Flavonoids / administration & dosage
Oxidative Stress
Signal Transduction
Tumor Necrosis Factor-alpha / physiology*
Vascular Diseases / prevention & control*
Grant Support
Reg. No./Substance:
0/Fish Oils; 0/Flavonoids; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Exp Diabetes Res
Journal ID (publisher-id): EDR
ISSN: 1687-5214
ISSN: 1687-5303
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright © 2012 H. Zhang and C. Zhang.
Received Day: 11 Month: 7 Year: 2011
Revision Received Day: 18 Month: 8 Year: 2011
Accepted Day: 24 Month: 8 Year: 2011
Print publication date: Year: 2012
Electronic publication date: Day: 1 Month: 11 Year: 2011
Volume: 2012E-location ID: 972679
ID: 3206370
PubMed Id: 22110483
DOI: 10.1155/2012/972679

Vasoprotection by Dietary Supplements and Exercise: Role of TNFα Signaling
Hanrui Zhang*
Cuihua Zhang
Division of Cardiovascular Medicine, Departments of Internal Medicine, Medical Pharmacology and Physiology, and Nutritional Sciences, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
Correspondence: *Hanrui Zhang:
[other] Academic Editor: Subrata Chakrabarti

1. Introduction

Endothelial dysfunction is an early indicator of cardiovascular diseases, including that seen in type 2 diabetes [1]. Accumulating evidence suggests that mediators of inflammation may be pathogenic by inducing vascular dysfunction [2]. Among the various inflammatory factors, tumor necrosis factor-alpha (TNFα) plays a pivotal role in the regulation of vascular function in various pathological status [3]. TNFα belongs to the TNF superfamily and is produced by many cell types, including macrophages, lymphocytes, and fibroblasts, and so forth [46]. TNFα can either exist in a membrane-bound form or be secreted as a soluble cytokine that is able to diffuse from the sites of its initial production [7]. It can bind to, and thus functions through its receptors, TNF receptor type 1 (TNFR1) and TNF receptor type 2 (TNFR2) [8]. Dietary supplements and exercise are emerging as effective adjunctive therapies targeting endothelial dysfunction and vascular wall inflammation [3, 9, 10]. This review summarized the vasoprotective effects of dietary supplements and exercises by inhibiting TNFα production and TNFα-induced signaling (Figures 1 and 2).

2. Dietary Supplements

During the past few decades, there has been renewed interest in dietary components that might favorably reduce risk of vascular dysfunction. Fish oil, dietary fiber, and various natural products have sparked intense interest in epidemiological studies. Extensive exploration of the underlying mechanisms of their healthy benefits became very important to develop new adjunctive therapies from those dietary supplements in order to delay or prevent the development of vascular disorders.

2.1. Fish Oil

Fish and other marine life serve as rich sources of a class of polyunsaturated fatty acids [11]. They are named as omega-3 or n-3 fatty acids because the first of the several double bonds occur three carbon atoms away from the terminal end of the carbon chain [11]. The three n-3 polyunsaturated fatty acids (n-3 PUFAs) include alpha linolenic acid (LNA), eicosapentenoic acid (EPA), and docosahexenoic acid (DHA) [12]. The role of fish oil lipids in regulating TNFα expression and TNFα-induced inflammation in vascular cells has been extensively studied in the past decades. Dietary supplementation with n-3 PUFA improved endothelial function and reduced circulating level of TNFα in offspring of patients with type 2 diabetes [13]. Omega-3 fatty acid markedly suppressed the production of TNFα by monocytes in response to endotoxin. In addition, it also significantly inhibited both monocyte-endothelium adhesion and transendothelial monocyte migration [14]. One of the mechanisms by which fish oil alters the ability of lymphocytes to bind to endothelial cells may be its effects on inhibiting adhesion molecule expression induced by proinflammatory cytokines such as TNFα [15, 16]. Moreover, dietary fish oil resulted in a 50% reduction in concanavalin A (Con A), which enhanced lymphocyte adhesion to TNFα-stimulated endothelial cells [17]. EPA and DHA inhibited TNFα-induced monocyte adhesion to activated endothelial cells in vitro by affecting endothelial platelet-activating factor (PAF) generation [18]. Dietary fish oil supplementation inhibited TNFα production by human peripheral blood mononuclear cells [19]. Acute cod liver oil consumption reduced circulating level of TNFα and intercellular adhesion molecule-1 (ICAM-1) in healthy individuals [20]. These studies suggest that inhibition of inflammatory cell adhesion/migration induced by inflammatory cytokine TNFα may partially explain the protective effects of the fish-oil-rich diet against vascular inflammation.

2.2. Dietary Fiber

A high intake of fiber-rich carbohydrates might contribute to weight management and is beneficial for reducing the risk of cardiovascular diseases and diabetes. As a mucilaginous material prepared from the seed husk of plants of the Plantago genus, psyllium is an excellent source of mainly soluble fiber. Prolonged feeding of a 3.5% P. ovata husk-supplemented diet prevented endothelial dysfunction and the development of hypertension in obese Zucker rats. The diet also decreased body weight gain, reduced hyperinsulinemia and dyslipidemia, restored plasma adiponectin concentration, and decreased circulating TNFα concentration [21]. In diabetic women, dietary intake of whole grain, bran, and cereal fibers decreased circulating C-reactive protein (CRP) and TNFR2 concentration [22].

2.3. Natural Products

There is a growing body of literature supporting the beneficial effects of natural products on optimal health and disease prevention. As a group of chemical substances found in plants, polyphenols are characterized by the presence of more than one phenol unit or building block per molecule. The health benefits of several specific polyphenols on vascular dysfunction are well established.

2.3.1. EGCG and other Flavonoid Polyphenolics

Flavonoids are most commonly known for their antioxidative and anti-inflammatory activity. Over 5000 naturally occurring flavonoids have been identified from various plants. Epigallocatechin gallate (EGCG), a green tea catechin, is the major component of green tea flavonoids. EGCG significantly attenuated the elevated TNFα levels and impaired vasodilator response to acetylcholine induced by low density lipoprotein (LDL) in a rat model [23]. EGCG decreases TNFα-induced fractalkine expression by suppressing nuclear factor-kappa B (NFκB) [24] and inhibited TNFα-induced monocyte chemoattractant protein-1 (MCP-1) production and the activation of activator protein-1 (AP-1) in vascular endothelial cells via heme oxygenase-1- (HO-1) dependent mechanisms [25, 26]. Apigenin is a flavone that is the aglycone of apiin. Apigenin profoundly reduced monocytes adhesion to human umbilical vein endothelial cells (HUVECs) monolayer by suppressing TNFα-stimulated upregulation of vascular cell adhesion protein-1 (VCAM-1), ICAM-1, and E-selectin mRNA expression [27]. As a flavonol, quercetin downregulated TNFα-induced ICAM-1 and E-selectin expression in human endothelial cells [2830]. Isoflavone genistein inhibited TNFα-induced apoptosis in human aortic endothelial cells as determined by caspase-3 activation, 7-amino actinomycin D staining, in situ apoptotic cell detection, and DNA laddering [31]. These studies provide a novel mechanism where flavonoids could provide direct vasoprotective benefits in inflammatory cardiovascular diseases by inhibiting TNFα and TNFα-induced inflammation.

2.3.2. Resveratrol and other Nonflavonoid Polyphenolics

For the last few decades, extensive work has been done to establish the biological activities and pharmacological actions of resveratrol and other nonflavonoid polyphenolics in protecting against vascular dysfunction in various disease states.

Resveratrol is a natural phytophenol that can be extracted from grape skins [32]. Epidemiological studies suggest that Mediterranean diet, which is rich in resveratrol, is associated with reduced risk of cardiovascular diseases [33]. Resveratrol ameliorated endothelial apoptosis by inhibiting TNFα-elicited increases in caspase-3/7 activity in endothelial cells and cultured rat aortas [34]. The protective effect of resveratrol was attenuated by the inhibition of glutathione peroxidase and HO-1, suggesting a role for antioxidant systems in the antiapoptotic action of resveratrol [34]. In addition to antiapoptotic effects, resveratrol inhibited TNFα-stimulated monocytes adhesion to endothelial cells [35]. The mechanism might be through inhibiting TNFα-induced NFκB activation and inflammatory gene expression [36]. Matrix metalloproteinases (MMPs) play an important role in extracellular matrix metabolism, which is a critical contributor to arterial pathology. Resveratrol dose-dependently suppressed TNFα-induced proliferation and expression of MMP-9 in vascular smooth muscle cells through the transcription factors NFκB and AP-1 [37]. Upregulated expression of fractalkine is associated with increased atherosclerotic lesion formation in apolipoprotein E−/− (ApoE−/−) mice [38]. Resveratrol strongly suppressed TNFα-induced fractalkine expression in endothelial cells through the suppression of NFκB and Sp1 transcription factor activities [39]. Resveratrol activates eNOS and increases muscle microvascular blood volume and flow via an NO-dependent mechanism, but systemic infusion of TNFα prevented resveratrol-induced muscle microvascular recruitment [40]. Therefore, resveratrol protected against TNFα-induced endothelial apoptosis, monocytes adhesion, cell proliferation, atherogenesis, and dysregulation of vasomotor function through multiple signaling pathways. Resveratrol also suppressed plasma TNFα concentration following inflammatory stimulation by lipopolysaccharide (LPS) [41] and modulates vascular TNFα expression [42]. Aortic TNFα expression was significantly increased in type 2 diabetic mice, accompanied by impaired endothelium-dependent vasorelaxation. Chronic resveratrol treatment improved endothelial function and reduced vascular TNFα expression [42]. Both anti-TNFα treatment and resveratrol markedly inhibited the NFκB pathway through suppressing inhibitor of NFκB (IκB) protein phosphorylation [42, 43], and significantly attenuated vascular oxidative stress and improved NO production. Thus, resveratrol mediated vasculoprotective effects by inhibiting TNFα expression and TNFα-induced signaling pathway.

Curcumin is another important natural polyphenol. It inhibited TNFα-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of NFκB activation [44, 45]. The mechanism was through inhibiting TNFα-induced IκBα degradation and the nuclear import of NFκB. In contrast, curcumin inhibited AP-1 by direct interaction of curcumin with AP-1 binding to its DNA binding motif, therefore, reduced the expression of endothelial tissue factor (TF), the central mediator of coagulation [46]. Thrombomodulin (TM) functions as a cofactor in the thrombin-induced activation of protein C in the antithrombotic pathway. Curcumin effectively blocked TNFα-induced downregulation of TM and endothelial protein C receptor (EPCR) at both mRNA and protein levels in several human endothelial cells [47]. Curcumin also reduced the intracellular reactive oxygen species (ROS) levels, phosphorylation of c-Jun N-terminal kinases (JNK), p38 mitogen-activated protein kinases (p38), and signal transducer and activator of transcription-3 (STAT3), and the expression of ICAM-1, MCP-1, interleukin-8 (IL-8), and lectin-like oxidised LDL receptor-1 (LOX-1) in TNFα-stimulated HUVECs [48, 49].

In summary, the anti-inflammatory, antithrombotic, antiapoptotic, and antioxidative effects contribute to the health benefits of those nutritional supplements, which protect against vascular damage at least partially by decreasing TNFα production and inhibiting TNFα-mediated pathological changes through multiple signaling pathways.

3. Exercise

There are dichotomies in the effects of exercise on the production of inflammatory cytokines. A cross-sectional study suggested that inflammatory markers, such as CRP, IL-6, and TNFα, were lower in older adults with higher levels of exercise and nonexercise activity and in antioxidant supplement users regardless of exercise level [50]. However, a study using treadmill running mice showed that exercise could increase plasma IL-6 concentrations and lung TNFα mRNA expression [51]. This dichotomy may be attributed to the intensity of exercise. Chronic heart failure is associated with increased levels of TNFα and markers of endothelial damage, including soluble ICAM-1 (sICAM-1) and E-selectin. Whereas acute bouts of exercise lead to an increase in proinflammatory cytokines and markers of endothelial damage; these effects were not seen when exercise was performed chronically in chronic heart failure patients [52]. A 10-week moderate intensity exercise training improved coronary arteriolar endothelial function and reduced TNFα level in the myocardial tissue homogenate of type 2 diabetic mice [53]. Interestingly, diet plus exercise training may exert remarkable benefits when either diet or exercise alone could not demonstrate evident benefits. In obese postmenopausal women, diet plus exercise, but not diet alone, decreased plasma levels of CRP, IL-6, sIL-6R, and sTNFR1 and increased basal and postreceptor stimulated lipolysis in both abdominal and gluteal regions [54]. After eccentric exercise in untrained men, Omega-3 fatty acids supplementation attenuates plasma TNFα level [55]. These results suggest that diet supplementation in exercise training is effective in reducing chronic inflammation.

4. Perspectives

It is of interest to notice that nutrition and exercise have almost always been studied separately although they are closely related and may amplify each other to maximize their beneficial effects. Studies of diet/dietary supplements plus exercise training in animals and human being subjects would be meaningful to explore the mechanisms of dietary supplements and exercise in protecting against vascular dysfunction and the involvement of TNFα signaling.

5. Concluding Remarks

In conclusion, TNFα is known to amplify several signaling pathways leading to vascular inflammation, apoptosis, oxidative stress, and thrombosis, which are key mediators in the pathogenesis of vascular dysfunction. Dietary supplements and/or exercise decrease TNFα level and inhibit TNFα-mediated pathological changes through multiple signaling pathways, whereby exerting vasoprotective benefits. We believe that further investigations in this exciting field would facilitate the development of dietary supplements and exercise as adjunctive therapies in the management of cardiovascular diseases.


This study was supported by NIH Grants (RO1-HL077566 and RO1-HL085119, to C. Zhang) and American Heart Association Predoctoral Fellowship (10PRE4300043 to H. Zhang).

1. Ding H,Triggle CR. Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endotheliumVascular Health and Risk ManagementYear: 200511557117319098
2. Sattar N. Inflammation and endothelial dysfunction: intimate companions in the pathogenesis of vascular disease?Clinical ScienceYear: 2004106544344514741042
3. Zhang H,Park Y,Wu J,et al. Role of TNF-α in vascular dysfunctionClinical ScienceYear: 2009116321923019118493
4. Parameswaran N,Patial S. Tumor necrosis factor-α signaling in macrophagesCritical Reviews in Eukaryotic Gene ExpressionYear: 20102028710321133840
5. von Fliedner V,Miescher S,Gerain J,et al. Production of tumor necrosis factor-α by naive or memory T lymphocytes activated via CD28Cellular ImmunologyYear: 199213911982071309488
6. Jaffré F,Callebert J,Sarre A,et al. Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1β, and tumor necrosis factor-α cytokine production by ventricular fibroblastsCirculationYear: 2004110896997415302781
7. Tumanov AV,Grivennikov SI,Kruglov AA,et al. Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organsBloodYear: 2010116183456346420634375
8. Tartaglia LA,Weber RF,Figari IS,Reynolds C,Palladino MA Jr.,Goeddel DV. The two different receptors for tumor necrosis factor mediate distinct cellular responsesProceedings of the National Academy of Sciences of the United States of AmericaYear: 19918820929292961718003
9. Woo KS,Chook P,Yu CW,et al. Effects of diet and exercise on obesity-related vascular dysfunction in childrenCirculationYear: 2004109161981198615066949
10. Watts K,Beye P,Siafarikas A,et al. Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescentsJournal of the American College of CardiologyYear: 200443101823182715145107
11. Stone NJ. Fish consumption, fish oil, lipids, and coronary heart diseaseCirculationYear: 1996949233723408901708
12. Kris-Etherton PM,Harris WS,Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular diseaseArteriosclerosis, Thrombosis, and Vascular BiologyYear: 2003232e20e30
13. Rizza S,Tesauro M,Cardillo C,et al. Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetesAtherosclerosisYear: 2009206256957419394939
14. Mayer K,Meyer S,Reinholz-Muhly M,et al. Short-time infusion of fish oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humansJournal of ImmunologyYear: 2003171948374843
15. Goua M,Mulgrew S,Frank J,Rees D,Sneddon AA,Wahle KWJ. Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids: involvement of the transcription factor NF-κB?Prostaglandins Leukotrienes and Essential Fatty AcidsYear: 20087813343
16. Wang TM,Chen CJ,Lee TS,et al. Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cellsJournal of Nutritional BiochemistryYear: 201122218719420573493
17. Sanderson P,Calder PC. Dietary fish oil diminishes lymphocyte adhesion to macrophage and endothelial cell monolayersImmunologyYear: 199894179879708190
18. Mayer K,Merfels M,Muhly-Reinholz M,et al. Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generationAmerican Journal of PhysiologyYear: 20022832H811H81812124231
19. James MJ,Gibson RA,Cleland LG. Dietary polyunsaturated fatty acids and inflammatory mediator productionAmerican Journal of Clinical NutritionYear: 200071supplement 1343S348S10617994
20. Papageorgiou N,Tousoulis D,Psaltopoulou T,et al. Divergent anti-inflammatory effects of different oil acute consumption on healthy individualsEuropean Journal of Clinical NutritionYear: 201165451451921326271
21. Galisteo M,Sánchez M,Vera R,et al. A diet supplemented with husks of Plantago ovata reduces the development of endothelial dysfunction, hypertension, and obesity by affecting adiponectin and TNF-α in Zucker ratsJournal of NutritionYear: 2005135102399240416177203
22. Qi L,van Dam RM,Liu S,Franz M,Mantzoros C,Hu FB. Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic womenDiabetes CareYear: 200629220721116443861
23. Tang WJ,Hu CP,Chen MF,Deng PY,Li YJ. Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor levelCanadian Journal of Physiology and PharmacologyYear: 200684216317116900942
24. Lee AS,Jung YJ,Kim DH,et al. Epigallocatechin-3-O-gallate decreases tumor necrosis factor-α- induced fractalkine expression in endothelial cells by suppressing NF-κBCellular Physiology and BiochemistryYear: 2009245-650351019910690
25. Zheng Y,Toborek M,Hennig B. Epigallocatechin gallate-mediated protection against tumor necrosis factor-α-induced monocyte chemoattractant protein-1 expression is heme oxygenase-1 dependentMetabolismYear: 201059101528153520580034
26. Ahn HY,Xu Y,Davidge ST. Epigallocatechin-3-O-gallate inhibits TNFα-induced monocyte chemotactic protein-1 production from vascular endothelial cellsLife SciencesYear: 20088217-1896496818397796
27. Lee JH,Zhou HY,Cho SY,Kim YS,Lee YS,Jeong CS. Anti-inflammatory mechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion moleculesArchives of Pharmacal ResearchYear: 200730101318132718038911
28. Kobuchi H,Roy S,Sen CK,Nguyen HG,Packer L. Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathwayAmerican Journal of PhysiologyYear: 19992773C403C41110484327
29. Mochizuki M,Kajiya K,Terao J,et al. Effect of quercetin conjugates on vascular permeability and expression of adhesion moleculesBioFactorsYear: 2004221–420120415630284
30. Takano-Ishikawa Y,Goto M,Yamaki K. Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-αPhytotherapy ResearchYear: 200317101224122714669262
31. Si H,Liu D. Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-α-induced apoptosis through the p38β mitogen-activated protein kinaseApoptosisYear: 2009141667619082897
32. Bertelli AA,Das DK. Grapes, wines, resveratrol, and heart healthJournal of Cardiovascular PharmacologyYear: 200954646847619770673
33. Simopoulos AP. What is so special about the diet of Greece? The scientific evidenceWorld Review of Nutrition and DieteticsYear: 200595809216151273
34. Ungvari Z,Orosz Z,Rivera A,et al. Resveratrol increases vascular oxidative stress resistanceAmerican Journal of PhysiologyYear: 20072925H2417H242417220179
35. Deng YH,Alex D,Huang HQ,et al. Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbenePhytotherapy ResearchYear: 201125345145720740479
36. Csiszar A,Smith K,Labinskyy N,Orosz Z,Rivera A,Ungvari Z. Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: role of NF-κB inhibitionAmerican Journal of PhysiologyYear: 20062914H1694H169916973825
37. Lee B,Moon SK. Resveratrol inhibits TNF-α-induced proliferation and matrix metalloproteinase expression in human vascular smooth muscle cellsJournal of NutritionYear: 2005135122767277316317118
38. Lesnik P,Haskell CA,Charo IF. Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesisJournal of Clinical InvestigationYear: 2003111333334012569158
39. Moon SO,Kim W,Sung MJ,et al. Resveratrol suppresses tumor necrosis factor-α-induced fractalkine expression in endothelial cellsMolecular PharmacologyYear: 200670111211916614140
40. Wang N,Ko SH,Chai W,et al. Resveratrol recruits rat muscle microvasculature via a nitric oxide-dependent mechanism that is blocked by TNFαAmerican Journal of PhysiologyYear: 20113001E195E20120978231
41. Marier JF,Chen K,Prince P,Scott G,del Castillo JRE,Vachon P. Production of ex vivo lipopolysaccharide-induced tumor necrosis factor-α, interleukin-1β, and interleukin-6 is suppressed by trans-resveratrol in a concentration-dependent mannerCanadian Journal of Veterinary ResearchYear: 200569215115415971681
42. Zhang H,Zhang J,Ungvari Z,Zhang C. Resveratrol improves endothelial function: role of TNFα and vascular oxidative stressArteriosclerosis, Thrombosis, and Vascular BiologyYear: 200929811641171
43. Zhang H,Park Y,Zhang C. Coronary and aortic endothelial function affected by feedback between adiponectin and tumor necrosis factor α in type 2 diabetic miceArteriosclerosis, Thrombosis, and Vascular BiologyYear: 2010301121562163
44. Kumar A,Dhawan S,Hardegen NJ,Aggarwal BB. Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)- mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-κB activationBiochemical PharmacologyYear: 19985567757839586949
45. Gupta B,Ghosh B. Curcuma longa inhibits TNF-α induced expression of adhesion molecules on human umbilical vein endothelial cellsInternational Journal of ImmunopharmacologyYear: 1999211174575710576620
46. Bierhaus A,Zhang Y,Quehenberger P,et al. The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-κBThrombosis and HaemostasisYear: 19977747727829134658
47. Nan B,Lin P,Lumsden AB,Yao Q,Chen C. Effects of TNF-α and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cellsThrombosis ResearchYear: 2005115541742615733976
48. Kim YS,Ahn Y,Hong MH,et al. Curcumin attenuates inflammatory responses of TNF-α-stimulated human endothelial cellsJournal of Cardiovascular PharmacologyYear: 2007501414917666914
49. Lee HS,Lee MJ,Kim H,et al. Curcumin inhibits TNFα-induced lectin-like oxidised LDL receptor-1 (LOX-1) expression and suppresses the inflammatory response in human umbilical vein endothelial cells (HUVECs) by an antioxidant mechanismJournal of Enzyme Inhibition and Medicinal ChemistryYear: 201025572072920163327
50. Colbert LH,Visser M,Simonsick EM,et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the health, aging and body composition studyJournal of the American Geriatrics SocietyYear: 20045271098110415209647
51. Colbert LH,Davis JM,Essig DA,Ghaffar A,Mayer EP. Tissue expression and plasma concentrations of TNFα, IL-1β, and IL-6 following treadmill exercise in miceInternational Journal of Sports MedicineYear: 200122426126711414667
52. Niebauer J,Clark AL,Webb-Peploe KM,Coats AJ. Exercise training in chronic heart failure: effects on pro-inflammatory markersEuropean Journal of Heart FailureYear: 20057218919315701465
53. Lee S,Park Y,Zhang C. Exercise training prevents coronary endothelial dysfunction in type 2 diabetic miceAmerican Journal of Biomedical Sciences34241252
54. You T,Berman DM,Ryan AS,Nicklas BJ. Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal womenJournal of Clinical Endocrinology and MetabolismYear: 20048941739174615070939
55. Tartibian B,Maleki BH,Abbasi A. Omega-3 fatty acids supplementation attenuates inflammatory markers after eccentric exercise in untrained menClinical Journal of Sport MedicineYear: 201121213113721358504

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