Document Detail

Vasopressor agents: old and new components.
MedLine Citation:
PMID:  15166834     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: In settings of cardiac arrest, reestablishing vital organ perfusion plays an important role in initial CPR. As a pharmacologic intervention, vasopressor agents aim to improve aortic diastolic pressure and, consequently, coronary and cerebral perfusion pressures. RECENT FINDINGS: Historically, adrenergic agonists such as epinephrine have been suggested for routine use in CPR. However, epinephrine's efficacy is controversial because of its unfavorable inotropic and chronotropic action. This has prompted research into the use of alternative pressor agents with more promising hemodynamic features; these include selective alpha 2-adrenergic agonists and other nonadrenergic vasoconstrictors such as vasopressin. SUMMARY: In this article, the main traditional and novel adrenergic and nonadrenergic vasopressor drugs are reviewed.
Lei Huang; Wanchun Tang
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in critical care     Volume:  10     ISSN:  1070-5295     ISO Abbreviation:  Curr Opin Crit Care     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-10-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9504454     Medline TA:  Curr Opin Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
The Institute of Critical Care Medicine, Palm Springs, California 92262, USA.
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MeSH Terms
Adrenergic Agents / classification,  pharmacology,  therapeutic use*
Cardiopulmonary Resuscitation / methods*
Critical Care / methods
Heart Arrest / drug therapy*,  therapy
Vasoconstrictor Agents / classification,  pharmacology,  therapeutic use*
Reg. No./Substance:
0/Adrenergic Agents; 0/Vasoconstrictor Agents

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