| Vasopressor use and effect on blood pressure after severe adult traumatic brain injury. | |
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MedLine Citation:
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PMID: 20878264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We describe institutional vasopressor usage, and examine the effect of vasopressors on hemodynamics: heart rate (HR), mean arterial blood pressure (MAP), intracranial pressure (ICP), cerebral perfusion pressure (CPP), brain tissue oxygenation (PbtO(2)), and jugular venous oximetry (SjVO(2)) in adults with severe traumatic brain injury (TBI). METHODS: We performed a retrospective analysis of 114 severely head injured patients who were admitted to the neurocritical care unit of Level 1 trauma center and who received vasopressors (phenylephrine, norepinephrine, dopamine, vasopressin or epinephrine) to increase blood pressure RESULTS: Phenylephrine was the most commonly used vasopressor (43%), followed by norepinephrine (30%), dopamine (22%), and vasopressin (5%). Adjusted for age, gender, injury severity score, vasopressor dose, baseline blood pressure, fluid administration, propofol sedation, and hypertonic saline infusion, phenylephrine use was associated with 8 mmHg higher mean arterial pressure (MAP) than dopamine (P = 0.03), and 12 mmHg higher cerebral perfusion pressure (CPP) than norepinephrine (P = 0.02) during the 3 h after vasopressor start. There was no difference in ICP between the drug groups, either at baseline or after vasopressor treatment. CONCLUSIONS: Most severe TBI patients received phenylephrine. Patients who received phenylephrine had higher MAP and CPP than patients who received dopamine and norepinephrine, respectively. |
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Authors:
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Pimwan Sookplung; Arunotai Siriussawakul; Amin Malakouti; Deepak Sharma; Jin Wang; Michael J Souter; Randall M Chesnut; Monica S Vavilala |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurocritical care Volume: 15 ISSN: 1556-0961 ISO Abbreviation: Neurocrit Care Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-11 Completed Date: 2012-01-19 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 101156086 Medline TA: Neurocrit Care Country: United States |
Other Details:
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Languages: eng Pagination: 46-54 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology* Brain Injuries / complications, physiopathology*, therapy* Dopamine / therapeutic use Female Heart Rate / physiology Humans Intracranial Pressure / physiology Male Norepinephrine / therapeutic use Phenylephrine / therapeutic use Retrospective Studies Vasoconstrictor Agents / therapeutic use* Vasopressins / therapeutic use Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS072308-01/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 11000-17-2/Vasopressins; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine |
| Comments/Corrections | |
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