Document Detail

Vasopressin and terlipressin: pharmacology and its clinical relevance.
MedLine Citation:
PMID:  15488059     Owner:  NLM     Status:  MEDLINE    
Vasopressin and its analogue, terlipressin, are potent vasopressors that may be useful therapeutic agents in the treatment of cardiac arrest, septic and catecholamine-resistant shock and oesophageal variceal haemorrhage. The aim of this article is to review the physiology and pharmacology of vasopressin and summarise its efficacy and safety in clinical trials and its subsequent therapeutic use. Recent studies indicate that the use of vasopressin during cardiopulmonary resuscitation may improve the survival of patients with asystolic cardiac arrest. Vasopressin deficiency can contribute to refractory shock states associated with sepsis, cardiogenic shock and cardiac arrest. Low doses of vasopressin and terlipressin can restore vasomotor tone in conditions that are resistant to catecholamines, with preservation of renal blood flow and urine output. They are also useful in reducing bleeding and mortality associated with oesophageal variceal haemorrhage. The long-term outcome of the use of these drugs is not known.
P C A Kam; S Williams; F F Y Yoong
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anaesthesia     Volume:  59     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-18     Completed Date:  2004-12-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  993-1001     Citation Subset:  AIM; IM    
Department of Anaesthesia, University of New South Wales, St George Hospital, Kogarah, New South Wales 2217, Australia.
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MeSH Terms
Esophageal and Gastric Varices / drug therapy
Heart Arrest / drug therapy
Lypressin / analogs & derivatives*,  pharmacology*
Shock / drug therapy
Vasoconstrictor Agents / pharmacology*
Vasopressins / pharmacology*,  physiology
Reg. No./Substance:
0/Vasoconstrictor Agents; 11000-17-2/Vasopressins; 14636-12-5/terlipressin; 50-57-7/Lypressin

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