| Vasopressin perfusion within the medial amygdaloid nucleus attenuates prostaglandin fever in the urethane-anaesthetized rat. | |
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MedLine Citation:
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PMID: 1525665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antipyretic effect of arginine vasopressin (AVP) introduced into the ventral septal area (VSA) by push-pull perfusion was investigated in the urethane-anaesthetized rat. In addition, experiments were carried out to determine whether AVP could suppress fever when similarly perfused within the medial amygdaloid nucleus (meA). During push-pull perfusion of artificial cerebrospinal fluid within the VSA or meA, PGE1 injected intracerebroventricularly evoked fevers with respective magnitudes of 1.3 +/- 0.2 degrees C and 1.4 +/- 0.3 degrees C above baseline. Perfusion of AVP (6.5 micrograms/ml) within the VSA had significantly reduced the magnitude of PGE1 fever to 0.3 +/- 0.3 degrees C above baseline, while having no significant effect on afebrile colonic temperature. Perfusion of AVP (6.5 micrograms/ml) within the meA had significantly attenuated the magnitude of PGE1 fever to 0.7 +/- 0.2 degrees C above baseline, while having no significant effect on afebrile colonic temperature. These results support further the utility of the urethane-anaesthetized rat model for future investigations of the central control of fever and antipyresis. In addition, these data are consistent with the hypothesis that AVP may act within the meA as an endogenous antipyretic. |
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Authors:
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P Federico; T J Malkinson; K E Cooper; Q J Pittman; W L Veale |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 587 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-10-22 Completed Date: 1992-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 319-26 Citation Subset: IM |
Affiliation:
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Health Sciences Centre, University of Calgary, Alberta, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alprostadil* Amygdala / anatomy & histology, physiology* Anesthesia Animals Arginine Vasopressin / administration & dosage, pharmacology* Body Temperature / drug effects Fever / chemically induced, prevention & control* Male Prosencephalon / anatomy & histology Rats Rats, Inbred Strains Urethane |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin; 51-79-6/Urethane; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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