Document Detail


Vasopressin induced myocardial depression in neurally mediated and not due to impaired coronary blood flow.
MedLine Citation:
PMID:  3801766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of the cardiodepressant effect of vasopressin was studied by measuring simultaneously myocardial contractile force and coronary blood flow (with tracer microspheres) in anaesthetized open-chest rabbits. Lysine-vasopressin administered at two dose levels (10 and 100 mu kg-1 infused in 2 min with a maintenance dose of 2 mu kg-1 min-1 between these two loading doses) to a group of 6 rabbits caused dose-dependent myocardial depression and also severely decreased coronary blood flow in a dose-dependent manner. Blood pressure remained almost unchanged but heart rate, cardiac output and total peripheral conductance were also decreased dose-dependently. In another group of 6 rabbits treated in the same way with lysine-vasopressin, darodipine (PY 108-068, 30 and 100 micrograms kg-1) was infused intravenously. It reversed the vasopressin-induced coronary constriction and cardiodepression. The high dose of vasopressin brought back cardiac depression but did not reduce coronary blood flow below baseline values. Myocardial depression could therefore not be adequately explained by the changes in coronary blood flow. In a further group of rabbits which had been subjected to cervical vagotomy and beta-adrenoceptor blockade (propranolol 1 mg kg-1 i.v.) before the experiment, vasopressin still caused coronary constriction which was reversed by darodipine, but had no effect on myocardial contractile force and heart rate. The cardiodepressant effect of vasopressin can thus be explained fully by effects on the autonomic nervous system which are reversed by lowering blood pressure, whereas the severe reduction of coronary flow did not contribute to the vasopressin-induced myocardial depression.
Authors:
R P Hof
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  87     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1987-03-02     Completed Date:  1987-03-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  611-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Arrhythmia Agents*
Calcium Channel Blockers / pharmacology
Coronary Circulation / drug effects*
Hemodynamics / drug effects
Lypressin / pharmacology*
Microspheres
Nifedipine / analogs & derivatives,  pharmacology
Rabbits
Reflex / drug effects
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 50-57-7/Lypressin; 72803-02-2/darodipine
Comments/Corrections

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