| Vasopressin in thermoregulation--competitive demands: experimental evidence and theoretical considerations. | |
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MedLine Citation:
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PMID: 1610776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have substantiated the antipyretic role played by extrahypothalamic limbic system (EXHY-LS) AVP during fever. Repeated attempts to elucidate other thermoregulatory functions of this hormone have failed. Circumstantial evidence, however, suggest central role for this hormone in thermoregulation under hypohydration. Hypohydration, hyperosmolarity and hypovolaemia induced upward shifts in temperature thresholds for activation of heat dissipating mechanisms. When hypovolaemia is superimposed on hyperosmolarity these shifts are additive. Analogously, these two stressors when combined, decrease the osmotic threshold for AVP release. In rats, the elevated temperature thresholds for evaporative cooling and peripheral vasodilation occurring with hypohydration are positively correlated with lower Hypothalamic/EXHY-LS AVP ratio. Reciprocal relations between limbic system and blood AVP contents suggest competitive interaction between central and peripheral demands. Hypothesis for the possible mode of action of central AVP in thermoregulation under hypohydration is discussed. |
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Authors:
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M Horowitz; Y Epstein; Y Shapiro |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 41 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 1992 |
Date Detail:
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Created Date: 1992-07-29 Completed Date: 1992-07-29 Revised Date: 2008-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 41-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Hadassah School of Dental Medicine, Hebrew University, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / physiology* Body Temperature Regulation / physiology* Humans |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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