Document Detail

Vasopressin in catecholamine-resistant septic and cardiogenic shock in very-low-birthweight infants.
MedLine Citation:
PMID:  16982509     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate vasopressin as a rescue therapy in catecholamine-refractory septic and cardiogenic shock in very-low-birthweight (VLBW) infants. METHODS: Prospective assessment of vasopressin therapy in three VLBW infants with catecholamine-refractory septic shock (24 + 6 wk, 600 g) and cardiogenic shock (26 + 1 wk, 890 g; 26 + 1 wk, 880 g) at a university hospital. RESULTS: Adequate systemic arterial blood pressure could only be restored after vasopressin administration as a continuous infusion over a 36-h period in the preterm suffering from septic shock; in the two neonates with cardiogenic shock, only a transient stabilization in mean arterial pressure was observed, which did not impact on the poor prognosis. CONCLUSION: Although vasopressin appears to be a suitable rescue therapy in catecholamine-resistant septic shock in VLBW infants, further evaluation in controlled clinical trials is warranted.
Sascha Meyer; Günther Löffler; Thorsten Polcher; Sven Gottschling; Ludwig Gortner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  95     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-19     Completed Date:  2007-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1309-12     Citation Subset:  IM    
Department of Neonatology and Paediatric Intensive Care, University Children's Hospital of Saarland, Homburg, Germany.
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MeSH Terms
Diseases in Twins / drug therapy
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*
Infant, Very Low Birth Weight*
Norepinephrine / therapeutic use
Shock, Cardiogenic / drug therapy*
Shock, Septic / drug therapy*
Treatment Failure
Vasoconstrictor Agents / therapeutic use*
Vasopressins / therapeutic use*
Reg. No./Substance:
0/Vasoconstrictor Agents; 11000-17-2/Vasopressins; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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