| Vasopressin gene expression in rats with experimental cirrhosis. | |
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MedLine Citation:
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PMID: 8423035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Impaired ability to excrete a water load occurs in a substantial number of patients with advanced cirrhosis and in animals with experimental cirrhosis. The nonosmotic stimulation of arginine vasopressin release from the pituitary has been implicated as an important factor in the abnormal water excretion in patients and animals with cirrhosis. In this study, arginine vasopressin hypothalamic gene expression was studied in cirrhotic rats. Cirrhosis was induced by a combination of phenobarbital treatment in drinking water and weekly intragastric administration of carbon tetrachloride for 13 to 15 wk. Severe cirrhosis was confirmed by morphological analysis and the presence of ascites. Plasma arginine vasopressin was also significantly higher in rats with cirrhosis (control = 1.77 +/- 0.16 and cirrhotic rats = 4.14 +/- 0.62 pg/ml, n = 9, p < 0.002). Hypothalamic arginine vasopressin messenger RNA was also significantly higher in cirrhotic rats (control = 762.1 +/- 132.3 and cirrhotic rats = 1,834.2 +/- 271.9 pg/hypothalamus, n = 9, p < 0.005). Pituitary arginine vasopressin content was significantly lowered in cirrhotic rats (control = 3.69 +/- 0.98 and cirrhotic rats = 1.57 +/- 0.09 micrograms/pituitary, n = 9, p < 0.05). No difference was seen in hypothalamic arginine vasopressin content between the two groups (control = 4.64 +/- 0.34 and cirrhotic rats = 4.23 +/- 0.33 ng/hypothalamus, n = 9, NS). Oxytocin messenger RNA in the hypothalamus was also not significantly different between the two groups (control = 8.61 +/- 0.68 and cirrhotic rats = 9.33 +/- 0.65 unit of density, n = 9, NS).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J K Kim; S N Summer; R L Howard; R W Schrier |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 17 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-02-24 Completed Date: 1993-02-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 143-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Colorado School of Medicine, Denver 80262. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / blood, genetics* Carbon Tetrachloride Gene Expression* Hypothalamus / metabolism Liver Cirrhosis, Experimental / blood, chemically induced, genetics* Male Nucleic Acid Hybridization Oxytocin / genetics Pituitary Gland / metabolism RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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DK 19928/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 113-79-1/Arginine Vasopressin; 50-56-6/Oxytocin; 56-23-5/Carbon Tetrachloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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