Document Detail

Vasopressin and fetal cerebrovascular regulation.
MedLine Citation:
PMID:  1510177     Owner:  NLM     Status:  MEDLINE    
Vasopressin (AVP) may increase cerebral blood flow (CBF) during hypoxemia by selective dilatation of cerebral vessels via endothelium-derived relaxing factor (EDRF) release. To test whether this action is relevant in the fetus, we produced isocapnic hypoxemia in halothane-anesthetized pregnant ewes. Fetal infusion of a V1 AVP antagonist reduced by 55% the increase in CBF during fetal hypoxemia. To test the role of this response during development, we examined the response to AVP in intact and endothelium-denuded femoral and basilar arterial rings in vitro from fetal, newborn, and adult sheep. AVP constricted femoral rings in an endothelium-independent manner, with increased potency in newborn and fetal compared with adult rings. AVP relaxed basilar rings in an endothelium-dependent manner, which was unaffected by indomethacin treatment, with increased potency in newborn and adult compared with fetal rings. We conclude that fetal cerebral vascular endothelium is functional and responsive to AVP and that circulating AVP during fetal hypoxemia contributes to increased CBF via this effect.
J C Eisenach; C Tong; D A Stump; S M Block
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  263     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-22     Completed Date:  1992-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R376-81     Citation Subset:  IM    
Department of Anesthesia, Wake Forest University Medical Center, Winston-Salem, North Carolina 27157.
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MeSH Terms
Anoxia / physiopathology
Arginine Vasopressin / antagonists & inhibitors,  physiology*
Basilar Artery / physiology
Cerebrovascular Circulation / physiology*
Endothelium, Vascular / physiology
Femoral Artery / physiology
Fetus / physiology*
Hemodynamics / physiology
Sheep / embryology
Grant Support
Reg. No./Substance:
113-79-1/Arginine Vasopressin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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