Document Detail

Vasopressin and atrial natriuretic hormone response to hypertonic saline during the follicular and luteal phases of the menstrual cycle.
MedLine Citation:
PMID:  8981117     Owner:  NLM     Status:  MEDLINE    
We studied the hormonal responses to hypertonic saline during the follicular (days 2-9) and luteal (days 21-28) phases of the menstrual cycle in nine healthy young women, aged 19-25 years. On both study days, each woman was infused with 5% hypertonic saline for 1 h at the rate of 0.1 ml/kg/min. Serum progesterone and oestradiol concentrations confirmed the reported stage of the menstrual cycle. No difference in weight or haematocrit was observed between the two stages of the study for each woman. Baseline blood pressure, serum sodium, plasma osmolality, plasma vasopressin and thirst levels were almost identical for both stages, and changed to the same degree during infusion of hypertonic saline. Baseline atrial natriuretic hormone concentrations were higher during the follicular phase and became significantly higher than during the luteal phase following infusion of hypertonic saline. We concluded that the intravascular volume during the luteal phase may be effectively decreased in comparison to the follicular phase.
W F Trigoso; J M Wesly; D L Meranda; Y Shenker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  11     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-20     Completed Date:  1997-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2392-5     Citation Subset:  IM    
Springfield Clinic, IL 62704, USA.
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MeSH Terms
Atrial Natriuretic Factor / blood*
Blood Pressure
Estradiol / blood
Follicular Phase / physiology*
Luteal Phase / physiology*
Osmolar Concentration
Progesterone / blood
Saline Solution, Hypertonic / administration & dosage,  diagnostic use*
Sodium / blood
Thirst / physiology
Vasopressins / blood*
Grant Support
Reg. No./Substance:
0/Saline Solution, Hypertonic; 11000-17-2/Vasopressins; 50-28-2/Estradiol; 57-83-0/Progesterone; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor

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