Document Detail


Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.
MedLine Citation:
PMID:  21820436     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière's disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases.
Authors:
Jérôme Nevoux; Marie Teixeira; Say Viengchareun; Claudine Cosson; Daniel Butlen; Marc Lombes; Evelyne Ferrary
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-31
Journal Detail:
Title:  FEBS letters     Volume:  -     ISSN:  1873-3468     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Affiliation:
UMR-S 867, Inserm, UFR de Médecine Paris Diderot, Site Xavier Bichat, 75018 Paris, France; UMR-S 867, Univ Paris Diderot, Paris, France; Inserm, U693, 94276, Le Kremlin Bicêtre, France; UMR-S693, Univ Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre 94276, France.
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