Document Detail

Vasopressin and A1 noradrenaline turnover during food or water deprivation in the rat.
MedLine Citation:
PMID:  11050685     Owner:  NLM     Status:  MEDLINE    
In the present study, we have examined in Wistar rats the effects of food or water deprivation of 3 days on the hypophyso-adrenal axis, vasopressinergic system and activity of A1 noradrenergic brain stem cell group, which is involved in the control of the hypothalamic neuro-endocrine activity. Levels of adrenocorticotropic hormone (ACTH) and vasopressin (AVP) were determined by radio-immunoassay, and corticosterone level was determined by fluorimetric method. Plasma levels of ACTH and corticosterone were greatly increased in both groups of rats. In water-deprived rats, plasma AVP (13.83 +/- 1.63 vs. 3.03 +/- 0.23 pg/ml) and osmolality levels were significantly elevated with a marked decrease of AVP hypophysis content (272 +/- 65 vs. 1098 +/- 75 ng/mg protein), but not in food-deprived rats in which osmolality did not change and AVP remained stocked (2082 +/- 216 ng/mg protein) in the hypophysis without release in the plasma (1.11 +/- 0.23 pg/ml). These observations indicated that both food-deprivation and water-deprivation stimulated the pituitary adrenal axis thereby suggesting a stress state. AVP production is stimulated both by fluid and food restriction but is secreted with differential effects: during food restriction AVP secretion is limited to supporting the hypothalamic pituitary-adrenal system.
S El Fazaa; N Gharbi; A Kamoun; L Somody
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  126     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2001-01-02     Completed Date:  2001-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  129-37     Citation Subset:  IM    
Département de Biologie, Faculté des Sciences, Tunis, Tunisia.
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MeSH Terms
Dehydration / metabolism*
Hypothalamo-Hypophyseal System / physiology
Norepinephrine / metabolism*
Pituitary-Adrenal System / physiology
Rats, Wistar
Starvation / metabolism*
Vasopressins / metabolism*
Reg. No./Substance:
11000-17-2/Vasopressins; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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