| Vasoparalysis associated with brain damage in asphyxiated term infants. | |
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MedLine Citation:
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PMID: 2115079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship of cerebral blood flow to acute changes in arterial carbon dioxide and mean arterial blood pressure (MABP) was determined during the first day of life in 19 severely asphyxiated term infants supported by mechanical ventilation. For comparison, 12 infants without perinatal asphyxia were also investigated. Global cerebral blood flow (CBF infinity) was determined by xenon 133 clearance two or three times within approximately 2 hours. During the cerebral blood flow measurement, the amplitude-integrated electroencephalogram and visual-evoked potential were recorded. Changes in arterial carbon dioxide pressure followed adjustments of the ventilator settings, whereas MABP fluctuated spontaneously. Arterial oxygen pressure and blood glucose concentration were in the normal range. Five of the asphyxiated infants had isoelectric electroencephalograms and died subsequently with severe brain damage. They had a high CBF infinity (mean 30.6 ml/100 gm/min) and abolished carbon dioxide and MABP reactivity. Lower CBF infinity (mean 14.7 ml/100 gm/min) and abolished MABP reactivity were found in another five asphyxiated infants with burst-suppression electroencephalograms in whom computed tomographic or clinical signs of brain lesions developed. The carbon dioxide reactivity was preserved in these infants. In the remaining nine asphyxiated infants without signs of central nervous system abnormality, carbon dioxide and MABP reactivity were preserved, as was also the case in the control group. We conclude that abolished autoregulation is associated with cerebral damage in asphyxiated infants and that the combination of isoelectric electroencephalograms and cerebral hyperperfusion is an early indicator of very severe brain damage. |
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Authors:
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O Pryds; G Greisen; H Lou; B Friis-Hansen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pediatrics Volume: 117 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-08-17 Completed Date: 1990-08-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 119-25 Citation Subset: AIM; IM |
Affiliation:
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Department of Neonatology, Rigshospitalet, Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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blood,
complications*,
physiopathology Blood Pressure / physiology Brain Damage, Chronic / etiology*, physiopathology Carbon Dioxide / blood Cerebrovascular Circulation / physiology* Electroencephalography Evoked Potentials, Visual / physiology Gestational Age Humans Infant, Newborn Oxygen / blood Vasomotor System / physiopathology* Xenon Radioisotopes / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Xenon Radioisotopes; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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