Document Detail

Vasomotor functions of skin microcirculation in vasospastic Raynaud's phenomena.
MedLine Citation:
PMID:  1789118     Owner:  NLM     Status:  MEDLINE    
An overview of our recent studies is given. The following subjects were investigated: Women with primary Raynaud's phenomenon (PRP) and their female controls (FC); vibration exposed workers without (HAV) and with vibration-induced white finger (VWF); men with chemotherapy-induced Raynaud's phenomenon (CRP) and men with similar treatment but without finger symptoms (CVB); and male controls (MC). All three forms of Raynaud's phenomenon (RP) had a vasospastic and not an obstructive disease. The relative capillary blood flow rate in the skin of the finger was measured by the local 133Xenon washout technique during three different postural stimuli before and after hand vibration and furthermore during hand vibration. The main results indicate a hyperreactivity of the central sympathetic nervous system in all three types of vasospastic RP, which may be responsible for episodes of RP; a dysfunction of the peripheral sensory nerve fibers in VWF; a chemotherapy-induced prolonged vascular-toxic effect only on the terminal arterioles regardless of finger symptoms; and an only transitory mechanical effect of hand vibration on the arteriolar vasomotor function. The applied quantitative mapping of the function levels of the different elements involved in sympathetic vasoconstriction may be valuable in the evaluation of the pathophysiological components in other forms of RP.
N Olsen; S W Hansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Scandinavica. Supplementum     Volume:  603     ISSN:  0302-2994     ISO Abbreviation:  Acta Physiol Scand Suppl     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-23     Completed Date:  1992-03-23     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  0376307     Medline TA:  Acta Physiol Scand Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital, Denmark.
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MeSH Terms
Cisplatin / adverse effects
Microcirculation / physiopathology
Middle Aged
Raynaud Disease / etiology,  physiopathology*
Skin / blood supply
Sympathetic Nervous System / physiopathology
Vasoconstriction / physiology
Vasomotor System / physiopathology
Vibration / adverse effects
Xenon Radioisotopes / diagnostic use
Reg. No./Substance:
0/Xenon Radioisotopes; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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