Document Detail


Vasomotor function after paclitaxel-coated balloon post-dilation in porcine coronary stent model.
MedLine Citation:
PMID:  21349465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this study was to evaluate endothelial function after post-dilation of bare-metal stents with paclitaxel-coated balloons (PCB) or non-drug-coated balloons (non-DCB) in a porcine model.
BACKGROUND: DCB are an attractive alternative to drug-eluting stents because they provide short duration of drug exposure, while potentially inhibiting in-stent restenosis. Drug-eluting stents are associated with impaired endothelial function. It is unknown whether this abnormal vasomotor function is mitigated by reduced duration of drug exposure.
METHODS: Thirteen pigs underwent bare-metal stent implantation (arteries, n = 30), followed by post-dilation with either PCB (SeQuent Please, B. Braun Melsungen AG, Berlin, Germany) (n = 17) or non-DCB (n = 13). Five pigs with unstented arteries (n = 14) were controls. Coronary vasomotion was assessed 1 month after stent implantation, using acetylcholine (Ach) and nitroglycerin. Measurements were obtained for distal segments.
RESULTS: Angiographic late loss and histological area stenosis were similar between PCB and non-DCB. However, the percentage of diameter change in response to Ach was diminished with PCB (p < 0.05), when compared with either non-DCB or naive arteries. There was no difference between non-DCB and naive arteries. Inflammatory score and intramural fibrin grading were significantly greater in PCB than non-DCB (p < 0.05). Additionally, inflammatory cell infiltration in the stented segments correlated with the degree of percentage of diameter change in response to Ach, at distal regions.
CONCLUSIONS: Post-dilation of bare-metal stents with PCB was associated with impaired vasodilatory response to Ach distal to the treated segments. Vasodilatory response after post-dilation with non-DCB was similar to control arteries.
Authors:
Takamitsu Nakamura; Brigitta C Brott; Irena Brants; Deepal Panchal; Jinsheng Li; Jack P Chen; Spencer B King; Nicolas Chronos; Dongming Hou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  4     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-25     Completed Date:  2011-06-28     Revised Date:  2012-08-29    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-55     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Affiliation:
Saint Joseph's Translational Research Institute/Saint Joseph's Hospital of Atlanta, Atlanta, Georgia 30313, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation*
Animals
Cardiovascular Agents / administration & dosage*
Coated Materials, Biocompatible*
Coronary Angiography
Coronary Vessels / drug effects*,  pathology,  physiopathology
Dose-Response Relationship, Drug
Endothelium, Vascular / drug effects*,  pathology,  physiopathology
Equipment Design
Linear Models
Models, Animal
Nitroglycerin / pharmacology
Paclitaxel / administration & dosage*
Swine
Time Factors
Vasodilation / drug effects*
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 0/Coated Materials, Biocompatible; 0/Vasodilator Agents; 33069-62-4/Paclitaxel; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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