| Vasomotor function after paclitaxel-coated balloon post-dilation in porcine coronary stent model. | |
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MedLine Citation:
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PMID: 21349465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The purpose of this study was to evaluate endothelial function after post-dilation of bare-metal stents with paclitaxel-coated balloons (PCB) or non-drug-coated balloons (non-DCB) in a porcine model. BACKGROUND: DCB are an attractive alternative to drug-eluting stents because they provide short duration of drug exposure, while potentially inhibiting in-stent restenosis. Drug-eluting stents are associated with impaired endothelial function. It is unknown whether this abnormal vasomotor function is mitigated by reduced duration of drug exposure. METHODS: Thirteen pigs underwent bare-metal stent implantation (arteries, n = 30), followed by post-dilation with either PCB (SeQuent Please, B. Braun Melsungen AG, Berlin, Germany) (n = 17) or non-DCB (n = 13). Five pigs with unstented arteries (n = 14) were controls. Coronary vasomotion was assessed 1 month after stent implantation, using acetylcholine (Ach) and nitroglycerin. Measurements were obtained for distal segments. RESULTS: Angiographic late loss and histological area stenosis were similar between PCB and non-DCB. However, the percentage of diameter change in response to Ach was diminished with PCB (p < 0.05), when compared with either non-DCB or naive arteries. There was no difference between non-DCB and naive arteries. Inflammatory score and intramural fibrin grading were significantly greater in PCB than non-DCB (p < 0.05). Additionally, inflammatory cell infiltration in the stented segments correlated with the degree of percentage of diameter change in response to Ach, at distal regions. CONCLUSIONS: Post-dilation of bare-metal stents with PCB was associated with impaired vasodilatory response to Ach distal to the treated segments. Vasodilatory response after post-dilation with non-DCB was similar to control arteries. |
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Authors:
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Takamitsu Nakamura; Brigitta C Brott; Irena Brants; Deepal Panchal; Jinsheng Li; Jack P Chen; Spencer B King; Nicolas Chronos; Dongming Hou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: JACC. Cardiovascular interventions Volume: 4 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-25 Completed Date: 2011-06-28 Revised Date: 2012-08-29 |
Medline Journal Info:
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Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 247-55 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Saint Joseph's Translational Research Institute/Saint Joseph's Hospital of Atlanta, Atlanta, Georgia 30313, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Angioplasty, Balloon, Coronary / adverse effects, instrumentation* Animals Cardiovascular Agents / administration & dosage* Coated Materials, Biocompatible* Coronary Angiography Coronary Vessels / drug effects*, pathology, physiopathology Dose-Response Relationship, Drug Endothelium, Vascular / drug effects*, pathology, physiopathology Equipment Design Linear Models Models, Animal Nitroglycerin / pharmacology Paclitaxel / administration & dosage* Swine Time Factors Vasodilation / drug effects* Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Coated Materials, Biocompatible; 0/Vasodilator Agents; 33069-62-4/Paclitaxel; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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