Document Detail


Vasomotor effects of iodinated contrast media: just side effects?
MedLine Citation:
PMID:  15320478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Routinely used iodinated contrast media have complex vasomotor effects on several arterial districts. All classes of iodinated radiographic contrast media are vasoactive, with iso-osmolar dimers inducing the smallest changes in vascular tone. The mechanisms responsible for contrast-induced vasomotor changes are not fully elucidated and are likely to be multifactorial. Although contrast-induced vasomotility is usually considered as an unwanted "side effect", recent findings suggest that it might indeed be useful in exploring the functional integrity of the vessel wall. We found that atherosclerosis has an impact on the type of the contrast-induced coronary vasomotor reaction. In fact, angiographically normal coronary segments show divergent vasomotor reactions to iodixanol or iopromide according to the presence/absence of, and distance from, a coronary atherosclerotic lesion located in their proximity. The mechanism responsible for this vasomotor effect does not apparently involve flow-mediated vasodilatation or endothelial nitric oxide synthesis. On the other hand, a cyclooxygenase product may be, at least in part, responsible for the vasodilating effect of non-ionic agents on epicardial coronary arteries, since contrast-induced vasodilatation is strongly inhibited in the presence of indomethacin. These findings have potential clinical implications, since the analysis of contrast-induced coronary vasomotion might result in a new test capable of evaluating vascular functional integrity. Such a test might be alternative or complementary to the tests based on muscarinic agonists (acetylcholine) or serotonin, which are known to evaluate the nitric oxide pathway.
Authors:
Ugo Limbruno; Raffaele De Caterina
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current vascular pharmacology     Volume:  1     ISSN:  1570-1611     ISO Abbreviation:  Curr Vasc Pharmacol     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-08-23     Completed Date:  2004-12-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101157208     Medline TA:  Curr Vasc Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  321-8     Citation Subset:  IM    
Affiliation:
Cardiac and Thoracic Department, the University of Pisa, Italy. ulimbru@tin.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Contrast Media / adverse effects*,  chemistry
Coronary Artery Disease / complications,  physiopathology
Coronary Circulation / drug effects
Coronary Vessels / drug effects,  metabolism,  physiopathology
Endothelium, Vascular / drug effects,  physiopathology
Humans
Iodine Compounds / adverse effects*,  chemistry
Muscle, Smooth, Vascular / drug effects,  physiopathology
Structure-Activity Relationship
Vasomotor System / drug effects*,  metabolism,  physiopathology
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Iodine Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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