Document Detail

Vasodilatory capacity and vascular structure in long-standing hypertension: a LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension.
MedLine Citation:
PMID:  12022241     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Flow-mediated dilatation (FMD), which is considered a measure of endothelial function, has been found impaired in hypertension. However, it is unclear whether this impairment is explained solely by endothelial dysfunction, or whether it is associated with structural vascular changes and reduced vasodilatory capacity. METHODS: In 42 unmedicated patients with hypertension and electrocardiographic left ventricular hypertrophy, we measured the following: 24-h ambulatory blood pressure (BP), minimal forearm vascular resistance (MFVR) by plethysmography, intima-media cross-sectional area of the common carotid arteries (IMA), FMD, and nitroglycerin-induced dilatation (NID) in the brachial artery by ultrasound. RESULTS: We found that FMD was correlated positively with NID (r = 0.38, P < .05). However, FMD as well as NID correlated negatively to 24-h systolic BP (r = -0.41, P = .01 and r = -0.52, P = .001), IMA/height (r = -0.41, P < .01 and r = -0.53, P < .001) and MFVR(men) (r = -0.44, P < .05 and r = -0.42, P < .05). CONCLUSIONS: Low FMD as well as low NID were related in parallel to high systolic BP and to the severity of vascular changes in different vascular beds, suggesting that elevated BP load in hypertension induces parallel abnormalities in conduit artery structure and overall vasodilatory capacity. Therefore, the decrease in FMD observed in severe hypertension may be caused by endothelial dysfunction as well as by structural vascular changes, suggesting difficulties in interpreting FMD solely as a measure of endothelial dysfunction in hypertensive patients with left ventricular hypertrophy.
Michael H Olsen; Kristian Wachtell; Christian Aalkjaer; Harriet Dige-Petersen; Jens Rokkedal; Hans Ibsen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  15     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-22     Completed Date:  2002-11-08     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  398-404     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark.
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MeSH Terms
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Brachial Artery / drug effects,  physiopathology,  ultrasonography
Carotid Artery, Common / ultrasonography
Chronic Disease
Hypertension / complications,  physiopathology*,  ultrasonography*
Hypertrophy, Left Ventricular / etiology
Middle Aged
Nitroglycerin / pharmacology
Regional Blood Flow / drug effects
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Vasodilation* / physiology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

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