Document Detail

Vasodilatory behavior of skeletal muscle arterioles in patients with nonedematous chronic heart failure.
MedLine Citation:
PMID:  3757189     Owner:  NLM     Status:  MEDLINE    
During maximal upright exercise, blood flow to working skeletal muscle is frequently reduced in patients with nonedematous chronic heart failure. It has been speculated that this reduced muscle flow may be caused in part by an intrinsic impairment of skeletal muscle vasodilatory capacity. To test this hypothesis, forearm blood flow and resistance were compared during forearm exercise and in response to transient forearm ischemia (10 min) in 22 patients with heart failure and in 11 normal subjects. During forearm exercise, both groups exhibited comparable forearm blood flows (ml/min/100 ml) (0.2 W: normal 5.9 +/- 3.1, heart failure 6.5 +/- 2.8; 0.4 W: normal 8.2 +/- 5.5, heart failure 8.2 +/- 3.6; 0.6 W: normal 11.5 +/- 6.8, heart failure 11.8 +/- 4.8 [all p = NS]) and forearm vascular resistance (mm Hg/ml/min/100 ml) (0.2 W: normal 23.1 +/- 12.4, heart failure 18.5 +/- 7.8; 0.4 W: normal 16.9 +/- 7.7, heart failure 14.7 +/- 6.4; 0.6 W: normal 13.1 +/- 7.7, heart failure 10.3 +/- 4.1 [all p = NS]). Ten minutes of forearm ischemia, an intervention that produces maximal forearm vasodilation, also resulted in comparable forearm vascular resistances in both groups (normal 4.1 +/- 2.4, heart failure 3.8 +/- 1.3 mm Hg/ml/min/100 ml/p = NS). These data suggest that skeletal muscle vasodilatory capacity is not intrinsically impaired in patients with nonedematous chronic heart failure.
J R Wilson; D H Wiener; L I Fink; N Ferraro
Related Documents :
10191969 - The role of exercise-based prognosticating algorithms in the selection of patients for ...
19672059 - Left-ventricular power-to-mass ratio at peak exercise predicts mortality, heart failure...
3526819 - Hemodynamic effects at rest and during exercise in long-term treatment with prazosin in...
9519349 - Effects of neurohormonal antagonism on symptoms and quality-of-life in heart failure.
9398099 - Effects of amlodipine in patients with chronic heart failure.
3552299 - Why patients with heart failure die: hemodynamic and functional determinants of survival.
10516539 - Perception of dyspnea during histamine- and methacholine-induced bronchoconstriction.
6820409 - Turnover of the fast components of myelin and myelin proteins in experimental hyperphen...
12271229 - Postnatal pelvic floor screening clinics: a pilot study.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  74     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-11-10     Completed Date:  1986-11-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  775-9     Citation Subset:  AIM; IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arterioles / physiopathology
Heart Failure / physiopathology*
Ischemia / physiopathology
Middle Aged
Muscles / blood supply*
Physical Exertion
Regional Blood Flow
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of coronary stenotic lesions on regional myocardial blood flow at rest.
Next Document:  Validation of continuous-wave Doppler echocardiographic measurements of mitral and tricuspid prosthe...