Document Detail


Vasodilatory behavior of skeletal muscle arterioles in patients with nonedematous chronic heart failure.
MedLine Citation:
PMID:  3757189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During maximal upright exercise, blood flow to working skeletal muscle is frequently reduced in patients with nonedematous chronic heart failure. It has been speculated that this reduced muscle flow may be caused in part by an intrinsic impairment of skeletal muscle vasodilatory capacity. To test this hypothesis, forearm blood flow and resistance were compared during forearm exercise and in response to transient forearm ischemia (10 min) in 22 patients with heart failure and in 11 normal subjects. During forearm exercise, both groups exhibited comparable forearm blood flows (ml/min/100 ml) (0.2 W: normal 5.9 +/- 3.1, heart failure 6.5 +/- 2.8; 0.4 W: normal 8.2 +/- 5.5, heart failure 8.2 +/- 3.6; 0.6 W: normal 11.5 +/- 6.8, heart failure 11.8 +/- 4.8 [all p = NS]) and forearm vascular resistance (mm Hg/ml/min/100 ml) (0.2 W: normal 23.1 +/- 12.4, heart failure 18.5 +/- 7.8; 0.4 W: normal 16.9 +/- 7.7, heart failure 14.7 +/- 6.4; 0.6 W: normal 13.1 +/- 7.7, heart failure 10.3 +/- 4.1 [all p = NS]). Ten minutes of forearm ischemia, an intervention that produces maximal forearm vasodilation, also resulted in comparable forearm vascular resistances in both groups (normal 4.1 +/- 2.4, heart failure 3.8 +/- 1.3 mm Hg/ml/min/100 ml/p = NS). These data suggest that skeletal muscle vasodilatory capacity is not intrinsically impaired in patients with nonedematous chronic heart failure.
Authors:
J R Wilson; D H Wiener; L I Fink; N Ferraro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  74     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-11-10     Completed Date:  1986-11-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  775-9     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arterioles / physiopathology
Heart Failure / physiopathology*
Humans
Ischemia / physiopathology
Middle Aged
Muscles / blood supply*
Physical Exertion
Regional Blood Flow
Vasodilation*
Grant Support
ID/Acronym/Agency:
5-M01-RR00040/RR/NCRR NIH HHS; HL-30665/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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