Document Detail

Vasodilator therapy: implications in acute myocardial infarction and congestive heart failure.
MedLine Citation:
PMID:  7039285     Owner:  NLM     Status:  MEDLINE    
The physiologic effects of systemic vasoconstriction on left ventricular performance and the salutary hemodynamic effect of acute administration of vasodilator drugs to patients with heart failure provide a rational basis for vasodilator therapy in acute myocardial infarction and chronic congestive heart failure. Use of vasodilators during the acute phase of myocardial infarction may reduce mortality when left ventricular filling pressure remains markedly elevated for at least 8 hours after the onset of clinical syndrome. Use of chronic vasodilator therapy in patients with congestive heart failure appears to have been effective in some patients in prolonging exercise tolerance; however, the likelihood of a beneficial effect and the impact of this therapy on the natural history of the disease remain unclear. A Veterans Administration Cooperative Study to address these questions is currently in progress. The new effort directed to studying the effects of vasodilator drugs in these syndromes has appropriately focused attention on their pathophysiology and natural history.
J N Cohn
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  103     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  773-8     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Heart Failure / drug therapy*
Hemodynamics / drug effects
Myocardial Infarction / drug therapy*
Nitroprusside / therapeutic use
Pulmonary Wedge Pressure / drug effects
Time Factors
Vasodilator Agents / therapeutic use*
Grant Support
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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