Document Detail


Vasodilator therapy after cardiac surgery: a review of the efficacy and toxicity of nitroglycerin and nitroprusside.
MedLine Citation:
PMID:  6769567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight-five patients who required vasodilator therapy in the postoperative period after cardiac surgery were studied to compare the haemodynamic effects of nitroglycerin and nitroprusside, to evaluate local and systemic toxicity, and to develop long-range dosage recommendations. Ninety-one per cent of the patients received the vasodilators for postoperative hypertension, while nine per cent had low output syndromes. Both drugs significantly decreased blood pressure and central venous pressure, and increased heart rate. Nitroglycerin decreased both right and left ventricular filling pressures more than nitroprusside. No local toxicity or methaemoglobinaemia was found with either drug. Elevated thiocyanate levels were detected in 44 per cent of the nitroprusside group; however, none of the patients developed progressive metabolic acidosis. For prolonged infusions we found that nitroprusside at 1 microgram.kg-1.min-1 and nitroglycerin at 0.5 microgram.kg-1.min-1 were without significant toxicity.
Authors:
J A Kaplan; D C Finlayson; S Woodward
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Anaesthetists' Society journal     Volume:  27     ISSN:  0008-2856     ISO Abbreviation:  Can Anaesth Soc J     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-08-15     Completed Date:  1980-08-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0371163     Medline TA:  Can Anaesth Soc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  254-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Cardiac Output, Low / drug therapy
Cardiac Surgical Procedures*
Central Venous Pressure / drug effects
Ferricyanides / pharmacology*
Hemodynamics / drug effects*
Humans
Hypertension / drug therapy
Middle Aged
Nitroglycerin / administration & dosage,  pharmacology*,  therapeutic use
Nitroprusside / administration & dosage,  pharmacology*,  therapeutic use
Postoperative Complications / drug therapy
Chemical
Reg. No./Substance:
0/Ferricyanides; 15078-28-1/Nitroprusside; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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