Document Detail

Vasodilator therapy for acute heart failure: haemodynamic comparison of hydralazine/isosorbide, alpha-adrenoceptor blockade, and angiotensin-converting enzyme inhibition.
MedLine Citation:
PMID:  1381019     Owner:  NLM     Status:  MEDLINE    
Haemodynamic comparison of three vasodilation regimens [intravenous (i.v.) hydralazine and isosorbide dinitrate (ISDN) combined, i.v. doxazosin, and i.v. enalaprilat] was undertaken in 36 patients with acute left ventricular (LV) failure due to recent myocardial infarction. Each regimen achieved similar reductions in pulmonary artery occluded pressure (PAOP, preload) and systemic arterial pressures (afterload), with increased cardiac and stroke volume (SV) indexes (p less than 0.01). Only the hydralazine and isosorbide combination induced resting tachycardia. Balanced vasodilatation after selective alpha-adrenoceptor blockade (doxazosin) and angiotensin-converting enzyme (ACE) inhibition (enalaprilat) without increase in heart rate (HR) suggests that these therapies may have definite haemodynamic advantages over the hydralazine/ISDN combination.
S P Verma; B Silke; G W Reynolds; J G Kelly; A Richmond; S H Taylor
Related Documents :
15785019 - A comparison of the two beta-blockers carvedilol and atenolol on left ventricular eject...
16812979 - Dual renin angiotensin system blockade in patients with acute myocardial infarction and...
22504219 - Behaviour of protein carbonyl groups in juvenile myocardial infarction.
9239429 - Cardiac disease in chronic uremia: management.
9554809 - Diminished responsiveness of gs-coupled receptors in severely failing human hearts: no ...
11641999 - Care of acute myocardial infarction in oklahoma: an update from the cooperative cardiov...
12796129 - Combined epicardial and endocardial electroanatomic mapping in a porcine model of heale...
23774549 - An autopsy case of secondary iron-overload cardiomyopathy.
10577449 - Mitral regurgitation after atrioventricular node catheter ablation for atrial fibrillat...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  20     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-01     Completed Date:  1992-10-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  274-81     Citation Subset:  IM    
University Department of Cardiovascular Studies, General Infirmary, Leeds, England.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic alpha-Antagonists / administration & dosage,  therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  therapeutic use*
Cardiac Output, Low / complications,  drug therapy*,  physiopathology
Drug Therapy, Combination
Enalaprilat / administration & dosage,  therapeutic use
Heart Rate / drug effects
Hemodynamics / drug effects*
Hydralazine / administration & dosage,  therapeutic use
Injections, Intravenous
Isosorbide Dinitrate / administration & dosage,  therapeutic use
Middle Aged
Myocardial Infarction / complications
Prazosin / administration & dosage,  analogs & derivatives,  therapeutic use
Pulmonary Wedge Pressure / drug effects
Vasodilator Agents / administration & dosage,  therapeutic use*
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Vasodilator Agents; 19216-56-9/Prazosin; 74191-85-8/Doxazosin; 84680-54-6/Enalaprilat; 86-54-4/Hydralazine; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of the effect of celiprolol and nifedipine on blood pressure and plasma lipids.
Next Document:  Comparison of peptide and nonpeptide receptor-mediated responses in rat tail artery.