Document Detail


Vasodilator therapy for acute heart failure: haemodynamic comparison of hydralazine/isosorbide, alpha-adrenoceptor blockade, and angiotensin-converting enzyme inhibition.
MedLine Citation:
PMID:  1381019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Haemodynamic comparison of three vasodilation regimens [intravenous (i.v.) hydralazine and isosorbide dinitrate (ISDN) combined, i.v. doxazosin, and i.v. enalaprilat] was undertaken in 36 patients with acute left ventricular (LV) failure due to recent myocardial infarction. Each regimen achieved similar reductions in pulmonary artery occluded pressure (PAOP, preload) and systemic arterial pressures (afterload), with increased cardiac and stroke volume (SV) indexes (p less than 0.01). Only the hydralazine and isosorbide combination induced resting tachycardia. Balanced vasodilatation after selective alpha-adrenoceptor blockade (doxazosin) and angiotensin-converting enzyme (ACE) inhibition (enalaprilat) without increase in heart rate (HR) suggests that these therapies may have definite haemodynamic advantages over the hydralazine/ISDN combination.
Authors:
S P Verma; B Silke; G W Reynolds; J G Kelly; A Richmond; S H Taylor
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  20     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-01     Completed Date:  1992-10-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  274-81     Citation Subset:  IM    
Affiliation:
University Department of Cardiovascular Studies, General Infirmary, Leeds, England.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / administration & dosage,  therapeutic use*
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  therapeutic use*
Cardiac Output, Low / complications,  drug therapy*,  physiopathology
Doxazosin
Drug Therapy, Combination
Enalaprilat / administration & dosage,  therapeutic use
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hydralazine / administration & dosage,  therapeutic use
Injections, Intravenous
Isosorbide Dinitrate / administration & dosage,  therapeutic use
Male
Middle Aged
Myocardial Infarction / complications
Prazosin / administration & dosage,  analogs & derivatives,  therapeutic use
Pulmonary Wedge Pressure / drug effects
Vasodilator Agents / administration & dosage,  therapeutic use*
Ventricular Function, Left / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Vasodilator Agents; 19216-56-9/Prazosin; 74191-85-8/Doxazosin; 84680-54-6/Enalaprilat; 86-54-4/Hydralazine; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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