Document Detail

Vasodilator properties of atrial natriuretic factor: a comparison with nitroglycerin, nitroprusside, and phentolamine during cardiopulmonary bypass.
MedLine Citation:
PMID:  2535309     Owner:  NLM     Status:  MEDLINE    
Thirty-five patients scheduled for coronary artery surgery were studied during hypothermic cardiopulmonary bypass (CPB) to compare the arteriolar and venodilator properties of a bolus dose of atrial natriuretic factor (ANF), 100 micrograms, with those of nitroglycerin, 200 micrograms, sodium nitroprusside, 120 micrograms, phentolamine, 3 mg, and placebo. A decrease observed in mean arterial pressure was used as an indicator of a decrease in systemic vascular resistance (arteriolar dilation), while a decrease in reservoir blood volume of the CPB circuit was considered to indicate an increase in venous capacitance (venodilation). All vasodilators decreased mean arterial pressure, and there was no difference in the maximal decrease of the pressure between the drugs. However, the decrease caused by ANF appeared later than that caused by the other vasodilators and lasted longer than with nitroglycerin and sodium nitroprusside. Nitroglycerin and sodium nitroprusside decreased reservoir blood volume, while ANF and phentolamine had no effect. It is concluded that ANF is an arteriolar dilator with a time profile of its effect differing from those of nitroglycerin, sodium nitroprusside, and phentolamine. ANF seems to have no venodilator activity in patients undergoing hypothermic CPB.
M Hynynen; R Palojoki; M Salmenperä; I Tikkanen; A Harjula; F Fyhrquist; J Heinonen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiothoracic anesthesia     Volume:  3     ISSN:  0888-6296     ISO Abbreviation:  J Cardiothorac Anesth     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1992-08-18     Completed Date:  1992-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709732     Medline TA:  J Cardiothorac Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  720-5     Citation Subset:  IM    
Department of Anaesthesia, Helsinki University Central Hospital, Finland.
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MeSH Terms
Atrial Natriuretic Factor / administration & dosage,  therapeutic use*
Blood Pressure / drug effects
Blood Volume / drug effects
Cardiopulmonary Bypass*
Coronary Artery Bypass
Injections, Intravenous
Middle Aged
Nitroglycerin / administration & dosage,  therapeutic use*
Nitroprusside / administration & dosage,  therapeutic use*
Phentolamine / administration & dosage,  therapeutic use*
Time Factors
Vasodilator Agents / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Placebos; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 50-60-2/Phentolamine; 55-63-0/Nitroglycerin; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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