Document Detail


Vasodilator and hypotensive effects of the optical isomers of nicardipine (YC-93), a new Ca2+-antagonist.
MedLine Citation:
PMID:  7131951     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vasodilator and hypotensive effects of (+) and (-) nicardipine were investigated in anesthetized dogs. When administered intravenously, (+) nicardipine was 3 times as potent as the (-) isomer in increasing vertebral blood flow and in lowering mean blood pressure. When injected into the vertebral artery, (+) nicardipine was also 3 times as potent as the (-) isomer in increasing vertebral blood flow. Upon both routes of administration, the duration of the action after (+) nicardipine was longer than that after the (-) isomer. However, there were no differences of plasma nicardipine levels after intravenous injection of both isomers to conscious beagle dogs. The LD50 values of (+) nicardipine in mice and rats upon intravenous injection were only 1.5-2 times smaller than those of the (-) isomer. These results indicate that there exists a stereoselectivity of vasodilator and hypotensive actions among the nicardipine isomers.
Authors:
T Takenaka; I Miyazaki; M Asano; S Higuchi; H Maeno
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  32     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  665-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Calcium Channel Blockers / blood,  pharmacology*
Dogs
Dose-Response Relationship, Drug
Female
Isomerism
Lethal Dose 50
Male
Mice
Mice, Inbred ICR
Nicardipine
Nifedipine / analogs & derivatives,  blood,  pharmacology*
Pyridines / pharmacology*
Rats
Rats, Inbred Strains
Structure-Activity Relationship
Vasodilator Agents / blood,  pharmacology*
Vertebral Artery / drug effects
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Pyridines; 0/Vasodilator Agents; 21829-25-4/Nifedipine; 55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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