| Vasodilator and hypotensive effects of the optical isomers of nicardipine (YC-93), a new Ca2+-antagonist. | |
| | |
MedLine Citation:
|
PMID: 7131951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Vasodilator and hypotensive effects of (+) and (-) nicardipine were investigated in anesthetized dogs. When administered intravenously, (+) nicardipine was 3 times as potent as the (-) isomer in increasing vertebral blood flow and in lowering mean blood pressure. When injected into the vertebral artery, (+) nicardipine was also 3 times as potent as the (-) isomer in increasing vertebral blood flow. Upon both routes of administration, the duration of the action after (+) nicardipine was longer than that after the (-) isomer. However, there were no differences of plasma nicardipine levels after intravenous injection of both isomers to conscious beagle dogs. The LD50 values of (+) nicardipine in mice and rats upon intravenous injection were only 1.5-2 times smaller than those of the (-) isomer. These results indicate that there exists a stereoselectivity of vasodilator and hypotensive actions among the nicardipine isomers. |
| | |
Authors:
|
T Takenaka; I Miyazaki; M Asano; S Higuchi; H Maeno |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Japanese journal of pharmacology Volume: 32 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 1982 Aug |
Date Detail:
|
Created Date: 1982-12-18 Completed Date: 1982-12-18 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 665-70 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects* Calcium Channel Blockers / blood, pharmacology* Dogs Dose-Response Relationship, Drug Female Isomerism Lethal Dose 50 Male Mice Mice, Inbred ICR Nicardipine Nifedipine / analogs & derivatives, blood, pharmacology* Pyridines / pharmacology* Rats Rats, Inbred Strains Structure-Activity Relationship Vasodilator Agents / blood, pharmacology* Vertebral Artery / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Calcium Channel Blockers; 0/Pyridines; 0/Vasodilator Agents; 21829-25-4/Nifedipine; 55985-32-5/Nicardipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Studies on chemotherapy of parasitic helminths (VII). Effects of various cholinergic agents on the m...
Next Document: A new device for the determination of microsomal cytochrome P-450 in renal tissue preparations from ...