| Vasodilator effect of pituitary adenylate cyclase activating polypeptide (PACAP) on femoral blood flow in dogs. | |
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MedLine Citation:
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PMID: 8101368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of PACAP, a new VIP-like neuropeptide, on femoral arterial blood flow was studied in anesthetized beagle dogs. Intra-arterial infusion of PACAP38, PACAP27, or VIP (0.25-25 pmol/kg) induced a dose-related increase in femoral blood flow. The dose-response curve for PACAP27 or PACAP38 was similar to that for VIP, but the response to PACAP38 at 25 pmol/kg was significantly less than the others. The vasodilator effect of PACAP38, however, lasted three to four times longer than that of PACAP27 or VIP. Vascular effects of PACAP38 and PACAP38(COOH) did not differ. PACAP(1-15), PACAP(10-20), PACAP(27-38), and PACAP(27-38)NH2 had little effect on blood flow. Thus, PACAP38 and PACAP27 are potent VIP-like vasodilators of the femoral arterial bed in dogs; PACAP38, but not PACAP27, differs from VIP in its prolonged vasodilator effect. |
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Authors:
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S Naruse; T Suzuki; T Ozaki; K Nokihara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peptides Volume: 14 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1993 May-Jun |
Date Detail:
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Created Date: 1993-08-16 Completed Date: 1993-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 505-10 Citation Subset: IM |
Affiliation:
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National Institute for Physiological Sciences, Okazaki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Pressure Dogs Femoral Artery / physiology Heart Rate Infusions, Intra-Arterial Neuropeptides / physiology* Neurotransmitter Agents / physiology* Pituitary Adenylate Cyclase-Activating Polypeptide Rheology Vasoactive Intestinal Peptide / physiology* Vasodilation / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 0/Neurotransmitter Agents; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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