| Vasodilator drug effects on internal mammary artery and saphenous vein grafts. | |
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MedLine Citation:
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PMID: 3130416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The internal mammary artery is a dynamic conduit used for myocardial revascularization in which potential exists for spasm as well as for vasodilation. This study investigated vasodilator drug effects on the mammary artery using nitroprusside and nitroglycerin in vitro to measure the inhibition of contraction of human internal mammary artery and in vivo to examine blood flow through a canine mammary artery. In the in vitro study, ring segments of human internal mammary arteries were suspended on strain gauges in muscle baths containing 37 degrees C Krebs solution for measurement of isometric tension in vitro. Arterial contraction was stimulated with 70 mM potassium and 10 microM norepinephrine, and inhibition of contraction by vasodilators was measured. Nitroprusside was more potent and effective than was nitroglycerin in inhibiting potassium and norepinephrine contraction. The in vivo study utilized a canine (n = 8) right heart bypass preparation that allowed precise control of cardiac output, blood pressure and heart rate, which were maintained constant. The internal mammary artery graft and the saphenous vein graft perfused the same coronary artery bed. Electromagnetic flow probes measured graft flow (with the other graft occluded) before and after 15 min of drug infusion (1 microgram/kg per min). Nitroglycerin significantly increased mammary artery flow 36 +/- 13%, whereas nitroprusside significantly decreased it 12 +/- 2%. Saphenous vein grafts responded differently; graft blood flow decreased with nitroglycerin and increased with nitroprusside. Thus, although nitroprusside was more effective than nitroglycerin in inhibiting mammary artery contraction in vitro, it decreased internal mammary artery graft flow measured in vivo. Nitroglycerin had the opposite effect, increasing mammary graft flow.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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G K Jett; J M Arcici; C R Hatcher; P W Abel; R A Guyton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 11 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-06-20 Completed Date: 1988-06-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1317-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Crawford W. Long Memorial Hospital, Emory University, Atlanta, Georgia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects Dogs Ferricyanides / pharmacology* Humans Mammary Arteries / drug effects*, transplantation Nitroglycerin / pharmacology* Nitroprusside / pharmacology* Norepinephrine / antagonists & inhibitors Potassium / antagonists & inhibitors Saphenous Vein / drug effects*, transplantation Spasm / drug therapy Thoracic Arteries / drug effects* Vascular Patency Vasoconstriction / drug effects Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Ferricyanides; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 55-63-0/Nitroglycerin; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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