| Vasodilator action of guinea pig vasoactive intestinal polypeptide (VIP): comparison with common mammalian VIP. | |
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MedLine Citation:
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PMID: 1289976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The vascular activity of guinea pig (gp) and common mammalian (p) VIP were compared in anesthetized guinea pigs and dogs. In the guinea pig, intravenous injections of gpVIP and pVIP increased pancreatic blood flow and reduced the systemic arterial pressure and pancreatic vascular resistance in a dose-related manner. There were no significant differences in the vasodilator actions of these two VIPs, indicating that the overall cardiovascular actions of gpVIP and pVIP are similar in guinea pigs. In the dog, gpVIP, when given intra-arterially, was less potent (about 1/4) than pVIP in its action on femoral blood flow, suggesting that the blood vessels of the dog hind leg are more sensitive to its own VIP than to gpVIP. Oxidation of pVIP and gpVIP with H2O2 greatly reduced their vasodilator effects on the femoral arterial blood flow. The vascular effects were restored to control levels by reduction of the oxidized peptides with mercaptoethanol, which suggests that methionine residues of gpVIP and pVIP are important in the vasodilator effect on the femoral arterial bed in dogs. |
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Authors:
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S Naruse; T Inoue; T Mochizuki; N Yanaihara |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Regulatory peptides Volume: 42 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-03-22 Completed Date: 1993-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 163-71 Citation Subset: IM |
Affiliation:
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National Institute for Physiological Sciences, Okazaki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects Blood Pressure / drug effects Dogs Femoral Artery / drug effects Guinea Pigs Injections, Intravenous Male Oxidation-Reduction / drug effects Pancreas / blood supply, drug effects Species Specificity Structure-Activity Relationship Vasoactive Intestinal Peptide / administration & dosage, chemistry, pharmacology* Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
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37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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