Document Detail

Vasodilator Effect of Phlomis bracteosa Constituents Is Mediated through Dual Endothelium-Dependent and Endothelium-Independent Pathways.
MedLine Citation:
PMID:  21967029     Owner:  NLM     Status:  Publisher    
This study describes the vasorelaxant potential of some pure compounds isolated from Phlomis bracteosa L.: marrubiin, phlomeoic acid, and two new constituents labeled as RA and RB. In rat thoracic aortic rings denuded of endothelium, marrubiin, phlomeoic acid, RA, and RB caused relaxation of high K(+) (80 mM) and phenylephrine (1 μM)-induced contractions at the concentration range of 1.0-1000 μg/mL. Marrubiin, phlomeoic acid, RA, and RB concentration dependently (3.0-10 μg/mL) shifted the Ca(++) curves to the right obtained in Ca(++)-free medium. The vasodilator effect of marrubiin, phlomeoic acid, RA, and RB was partially blocked by N(ω)-nitro-L-arginine methyl ester in endothelium-intact aorta preparations. These results reveal that P. bracteosa constituents: marrubiin, phlomeoic acid, RA, and RB exhibit vasodilator action occurred via a combination of endothelium-independent Ca(++) antagonism and endothelium-dependent N(ω)-nitro-L-arginine methyl ester-sensitive nitric oxide-modulating mechanism.
Arif-Ullah Khan; Riaz Ullah; Asifullah Khan; Mohamad Rais Mustafa; Javid Hussain; Dharmani Devi Murugan; A Hamid Bin A Hadi
Related Documents :
7942579 - Human subcutaneous adipose tissue shows site-specific differences in fatty acid composi...
7445529 - The role of lipophilicity in the extrahepatic disposition of aminostilbene derivatives ...
16658839 - Change in invertase activity of sweet potato in response to wounding and purification a...
14961229 - Synthesis of the neurotoxin quinolinic acid in apoptotic tissue from suberites domuncul...
16659049 - A kinetic analysis of the effects of gibberellic acid, zeatin, and abscisic acid on lea...
8843749 - Regulation of lipid metabolism in adipose tissue during early starvation.
22064149 - Effect of different feeds on meat quality and fatty acid composition of lambs fattened ...
759179 - Propionyl-coa carboxylase deficiency with overflow of metabolites of isoleucine catabol...
22560349 - Simultaneous extraction and derivatization of amino acids and free fatty acids in meat ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-3
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  -     ISSN:  1525-6006     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Center for Natural Products Research and Drug Discovery, Department of Pharmacology, Faculty of Medicine, University of Malaya , Kuala Lumpur , Malaysia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Frequency Ranges of Heart Rate Variability Related to Autonomic Nerve Activity in the Mouse.
Next Document:  Validation of the Parama-Tech PS-501 Device for Office Blood Pressure Measurement According to the I...