Document Detail

Vasodilative effect of adrenomedullin in isolated arteries of the dog.
MedLine Citation:
PMID:  7630044     Owner:  NLM     Status:  MEDLINE    
Adrenomedullin is known to induce profound hypotension in vivo, but the direct effect of this peptide on isolated arteries has not been demonstrated. This study estimated the vasodilative effects of adrenomedullin in comparison with those of calcitonin gene-related peptide (CGRP) in basilar, mesenteric, coronary, renal and femoral arteries isolated from the dog. Adrenomedullin (3 to 100 nM) and CGRP (1 to 30 nM) induced concentration-dependent relaxation of these arteries with and without endothelium, and the relaxing effects were slightly greater in endothelium-intact arteries than in denuded ones. The vasodilative potency of adrenomedullin relative to CGRP was smaller in the femoral artery than in basilar, mesenteric, coronary and renal arteries.
K Nakamura; H Toda; K Terasako; M Kakuyama; Y Hatano; K Mori; K Kangawa
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  67     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-09-05     Completed Date:  1995-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
Department of Anesthesia, Kyoto University Hospital, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Arteries / drug effects*
Calcitonin Gene-Related Peptide / pharmacology
Endothelium, Vascular / physiology
Peptides / pharmacology*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Peptides; 0/Vasodilator Agents; 148498-78-6/Adrenomedullin; 83652-28-2/Calcitonin Gene-Related Peptide

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