Document Detail

Vasodilating effects of carbon monoxide.
MedLine Citation:
PMID:  3243186     Owner:  NLM     Status:  MEDLINE    
The vasodilator effects of carbon monoxide (CO) were studied in an isolated perfused rat thoracic aorta preparation. Thoracic aortas from male Sprague-Dawley laboratory rats were dissected free of surrounding tissue, cannulated proximally, and tethered to in situ length. The vessels were perfused with oxygenated Krebs-Henseleit (KH) solution at 37 degrees C in a constant flow system with a circumferentially-applied, pulsatile (300/min), basal "systolic" pressure of 100 mm Hg. Aortas were precontracted with high-potassium (K+) or norepinephrine (NE). Changes in perfusion pressure were indicative of changes in vascular resistance induced by the test gas mixtures. Oxygen (O2) content of the perfusate was kept constant, while CO and nitrogen (N2) were altered. CO (2.5, 5 and 10%) dilated both K+-contracted and NE-contracted aortas in a dose-dependent manner. A significant vasodilation in response to 5% CO (24.5% of maximal), but not to 5% N2, was obtained in the K+-contracted aortas. After the endothelium was removed chemically, the aortas continued to dilate in response to CO. These results suggest that CO has a direct vasorelaxant effect on vascular smooth muscle which is nonspecific and is not endothelium-dependent.
H Lin; J J McGrath
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  11     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  371-85     Citation Subset:  IM    
Department of Physiology, Texas Tech University Health Sciences Center, Lubbock 79430.
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MeSH Terms
Carbon Monoxide / toxicity*
Endothelium, Vascular / drug effects
Muscle, Smooth, Vascular / drug effects*
Norepinephrine / antagonists & inhibitors
Potassium / antagonists & inhibitors
Rats, Inbred Strains
Vasodilation / drug effects*
Grant Support
5T32 HL 07289-09/HL/NHLBI NIH HHS
Reg. No./Substance:
51-41-2/Norepinephrine; 630-08-0/Carbon Monoxide; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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