| Vasodilating dipeptide Trp-His can prevent atherosclerosis in apo E-deficient mice. | |
| | |
MedLine Citation:
|
PMID: 19728894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Most of the investigations for an alternative medicinal treatment on atherosclerosis have been focused on natural or dietary compounds including phytochemicals. So far, few studies regarding anti-atherosclerotic small peptides except for tetrapeptide of Lys-Arg-Glu-Ser have been reported. The present study was, thus, to investigate whether dipeptide Trp-His, which is one of vasodilating small peptides, could reduce atherosclerotic lesions in apo E-deficient mice fed a high-fat diet. The animal study involved a 9-week-successive administration of Trp-His at a dose of 0, 10 or 100 mg/kg per d. After 9-week administration, en face analyses provided the first direct evidence that the atherosclerotic lesion area was significantly reduced by 27 and 38 % for Trp-His dosed at 10 and 100 mg/kg per d, respectively, compared with the control group. Administration of Trp-His did not affect growth parameters such as body weight and feeding efficiency (P>0.1). Total serum cholesterol and HDL-cholesterol as well as lipid profiles in the liver did not differ between the tested groups. Taken together, the anti-atherosclerotic effect of dipeptide Trp-His should be addressed into physiological functions of bioactive peptides, in which the dipeptide may elicit the power by alternative mechanism(s), not by the regulation of lipid metabolism. |
| | |
Authors:
|
Toshiro Matsui; Masao Sato; Mitsuru Tanaka; Yasuna Yamada; Shimpei Watanabe; Yumiko Fujimoto; Katsumi Imaizumi; Kiyoshi Matsumoto |
Related Documents
:
|
2337384 - Anti-atherosclerotic activity of colestipol hydrochloride in sea quail. 323454 - An in vivo comparison of chlorhexidine and picloxydine mouthrinses: a possible associat... 10071704 - The use of antioxidants in retarding atherosclerosis: fact or fiction? 10545674 - Effect of antioxidant vitamin e as a protective factor in experimental atherosclerosis ... 4076934 - Aflatoxin deposition and clearance in the eggs of laying hens. 19022954 - 9-cis retinoic acid reduces 1alpha,25-dihydroxycholecalciferol-induced renal calcificat... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-04 |
Journal Detail:
|
Title: The British journal of nutrition Volume: 103 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-26 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 309-13 Citation Subset: IM |
Affiliation:
|
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812-8581, Japan. tmatsui@agr.kyushu-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apolipoproteins E / deficiency* Atherosclerosis / blood, pathology, prevention & control* Cholesterol / blood Cholesterol, HDL / blood Dipeptides / therapeutic use* Lipids / blood, physiology Liver / metabolism Male Mice Mice, Knockout Oligopeptides / therapeutic use Sinus of Valsalva / pathology Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins E; 0/Cholesterol, HDL; 0/Dipeptides; 0/Lipids; 0/Oligopeptides; 0/Vasodilator Agents; 0/tryptophyl-histidine; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells.
Next Document: Effect of seaweed and cholesterol-enriched diets on postprandial lipoproteinaemia in rats.