Document Detail

Vasodilatation, not hypotension, improves resistance vessel design during treatment of essential hypertension: a literature survey.
MedLine Citation:
PMID:  11403346     Owner:  NLM     Status:  MEDLINE    
Correction of structural abnormalities in resistance arteries of patients with essential hypertension is a potential treatment goal, in addition to blood pressure reduction. However, available evidence from human as well as from animal studies indicates that antihypertensive therapy is not always accompanied by normalization of resistance vessel structure, despite normalization of blood pressure. Thus, blood pressure is not the only factor determining resistance vessel structure, and experimental studies show that several factors could play a role, including shear stress and hormonal stimulation. To date, there has been no systematic review of the many published papers which have studied the structural effects of antihypertensive therapy, and it is not known which conditions are best able to normalize resistance vessel structure. We have therefore made a survey of the available literature. The survey shows that change in blood pressure in indeed a poor indicator of change in resistance vessel structure. However, it is a remarkably consistent finding that normalization of resistance vessel structure is obtained with therapeutic regimens which reduce blood pressure by vasodilation rather than by lowering cardiac output Thus, to the extent that normalization of resistance vessel structure is deemed a goal of antihypertensive treatment, the survey points towards the importance of considering not only the treatment effect on blood pressure, but also the haemodynamic effects within patients with essential hypertension.
K L Christensen; M J Mulvany
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  19     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1001-6     Citation Subset:  IM    
Department of Pharmacology, University of Aarhus, Denmark.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Arteries / drug effects,  pathology,  physiopathology
Blood Pressure / drug effects,  physiology
Hypertension / drug therapy*,  pathology*,  physiopathology
Vascular Resistance / drug effects,  physiology
Vasodilation* / drug effects,  physiology
Reg. No./Substance:
0/Antihypertensive Agents
Erratum In:
J Hypertens 2001 Sep;19(9):1697

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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