Document Detail

Vasodepressor role of endogenous bradykinin assessed by a bradykinin antagonist.
MedLine Citation:
PMID:  3021624     Owner:  NLM     Status:  MEDLINE    
This study was designed to examine the contribution of bradykinin to the depressor effect of different antihypertensive drugs in two-kidney renovascular hypertensive rats, using a new specific antagonist of bradykinin. First, the inhibitory capacity of this peptide for exogenously injected bradykinin (75-200 ng) was tested. An inhibition of the vasodepressor action of bradykinin by over 50% was found when the bradykinin inhibitor was infused at a rate of 40 micrograms/min, with little difference at higher rates of infusion. This inhibitor then was infused in three groups of renovascular hypertensive rats after their blood pressure had been decreased by pretreatment with the converting enzyme inhibitor enalapril (MK 421), saralasin, or sodium nitroprusside, respectively. Infusion of the inhibitor produced an immediate 30% increase in blood pressure only in the enalapril-treated group. These results indicate that bradykinin is involved in the decrease of blood pressure produced by converting enzyme inhibition in experimental renovascular hypertension.
A Benetos; H Gavras; J M Stewart; R J Vavrek; S Hatinoglou; I Gavras
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  8     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-05     Completed Date:  1986-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  971-4     Citation Subset:  IM    
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors*
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Bradykinin / antagonists & inhibitors,  physiology*
Enalapril / pharmacology
Hypertension, Renovascular / physiopathology*
Nitroprusside / pharmacology
Oligopeptides / pharmacology*
Rats, Inbred Strains
Saralasin / pharmacology
Grant Support
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Oligopeptides; 103433-42-7/B 4146; 15078-28-1/Nitroprusside; 34273-10-4/Saralasin; 58-82-2/Bradykinin; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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