Document Detail


Vasodepressor property of the converting enzyme inhibitor captopril (SQ 14 225): the role of factors other than renin-angiotensin blockade in the rat.
MedLine Citation:
PMID:  6986224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The peptide converting enzyme inhibitor captopril was given (1.25 mg/kg intravenously) to normal and nephrectomized rats and rats with renovascular and deoxycorticosterone hypertension. 2. Captopril lowered blood pressure to a small extent in normal and nephrectomized rats. Bradykinin infusion in nephrectomized animals, however, potentiated the vasodepressor action of captopril. 3. Captopril produced a major blood pressure fall in the early stages of Goldblatt two-kidney one-clip hypertension: even when hypertension had been present for more than 4 months, a substantial vasodepressor action was seen. Rats with deoxycorticosterone-induced hypertension also showed a significant blood pressure fall. 4. Captopril was given to salt-loaded and salt-depleted rats in which the renin-angiotensin system had been blocked by infusion of the competitive angiotensin II antagonist saralasin. Captopril still lowered blood pressure in the salt-depleted group. 5. Captopril lowers blood pressure in situations where the renin-angiotensin system is not responsible for blood pressure maintenance. Further, the fall in blood pressure produced in Goldblatt two-kidney one-clip hypertension is greater than would be predicted on the basis of renin-angiotensin blockade. It is likely therefore that captopril lowers blood pressure by an action additional to angiotensin blockade. Bradykinin potentiation is one possible mechanism by which this may take place.
Authors:
E S Marks; R F Bing; H Thurston; J D Swales
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  58     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1980 Jan 
Date Detail:
Created Date:  1980-04-26     Completed Date:  1980-04-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / pharmacology
Animals
Blood Pressure / drug effects*
Bradykinin / pharmacology
Captopril / pharmacology*
Disease Models, Animal
Female
Hypertension / blood,  physiopathology*
Nephrectomy
Proline / analogs & derivatives*
Rats
Renin / blood
Saralasin / pharmacology
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 147-85-3/Proline; 34273-10-4/Saralasin; 58-82-2/Bradykinin; 62571-86-2/Captopril; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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