| Vasodepressor property of the converting enzyme inhibitor captopril (SQ 14 225): the role of factors other than renin-angiotensin blockade in the rat. | |
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MedLine Citation:
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PMID: 6986224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The peptide converting enzyme inhibitor captopril was given (1.25 mg/kg intravenously) to normal and nephrectomized rats and rats with renovascular and deoxycorticosterone hypertension. 2. Captopril lowered blood pressure to a small extent in normal and nephrectomized rats. Bradykinin infusion in nephrectomized animals, however, potentiated the vasodepressor action of captopril. 3. Captopril produced a major blood pressure fall in the early stages of Goldblatt two-kidney one-clip hypertension: even when hypertension had been present for more than 4 months, a substantial vasodepressor action was seen. Rats with deoxycorticosterone-induced hypertension also showed a significant blood pressure fall. 4. Captopril was given to salt-loaded and salt-depleted rats in which the renin-angiotensin system had been blocked by infusion of the competitive angiotensin II antagonist saralasin. Captopril still lowered blood pressure in the salt-depleted group. 5. Captopril lowers blood pressure in situations where the renin-angiotensin system is not responsible for blood pressure maintenance. Further, the fall in blood pressure produced in Goldblatt two-kidney one-clip hypertension is greater than would be predicted on the basis of renin-angiotensin blockade. It is likely therefore that captopril lowers blood pressure by an action additional to angiotensin blockade. Bradykinin potentiation is one possible mechanism by which this may take place. |
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Authors:
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E S Marks; R F Bing; H Thurston; J D Swales |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 58 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-04-26 Completed Date: 1980-04-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology Animals Blood Pressure / drug effects* Bradykinin / pharmacology Captopril / pharmacology* Disease Models, Animal Female Hypertension / blood, physiopathology* Nephrectomy Proline / analogs & derivatives* Rats Renin / blood Saralasin / pharmacology |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 147-85-3/Proline; 34273-10-4/Saralasin; 58-82-2/Bradykinin; 62571-86-2/Captopril; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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