| Vasodepression ex vivo after administration of inflammatory mediators in vivo in the rat. | |
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MedLine Citation:
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PMID: 2476918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When rats were pretreated by intraplantar or i.v. injection of various inflammatory mediators, the vasopressor effect of i.a. norepinephrine in the subsequently isolated perfused hindlegs of the rats was found to be partly depressed. This vasodepression could also be detected if mediators were directly co-perfused in the isolated hindlegs. The vasodepressor effect was strongest following histamine pretreatment and co-perfusion, respectively, whereas endotoxin 0111:B4, PAF-acether, PGE1, and LTD4 were less effective. Only weak or no vasodepression could be induced by bradykinin, serotonin, lysolecithin, and substance P (1-11). The significance of the results is discussed with respect to anaphylactic disorders. |
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Authors:
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H Bekemeier; J U Sänze |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Agents and actions Volume: 28 ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-10-26 Completed Date: 1989-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 103-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Martin Luther University, Halle, GDR. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alprostadil
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pharmacology Animals Biological Factors / pharmacology* Bradykinin / pharmacology Endotoxins / pharmacology Epoprostenol / pharmacology Escherichia coli Female Histamine / pharmacology Inflammation / physiopathology* Norepinephrine / pharmacology Platelet Activating Factor / pharmacology Rats SRS-A / pharmacology Serotonin / pharmacology Substance P / pharmacology Vasoconstriction / drug effects* p-Methoxy-N-methylphenethylamine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Biological Factors; 0/Endotoxins; 0/Platelet Activating Factor; 0/SRS-A; 33507-63-0/Substance P; 35121-78-9/Epoprostenol; 4091-50-3/p-Methoxy-N-methylphenethylamine; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 51-45-6/Histamine; 58-82-2/Bradykinin; 67924-63-4/endotoxin, Escherichia coli; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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