Document Detail

Vasoconstrictive effect of portal blood in isolated dog kidney.
MedLine Citation:
PMID:  3162765     Owner:  NLM     Status:  MEDLINE    
Humoral vasoactive substances coming from portal blood have been considered as a possible cause of renal dysfunction in cirrhotic patients. We have thus investigated the effect of perfusion of portal blood from anesthetized dogs on the isolated kidney functions. Both kidneys of a dog were simultaneously perfused on 2 Nizet's pump oxygenators, one kidney serving as control for the other. Renal blood flow was decreased in kidneys perfused with portal blood, as compared to the paired control kidneys perfused with sus-hepatic blood (group A experiments). Addition of polymyxin B to the portal blood restored the renal blood flow to the control level (group B experiments). No significant changes appeared between experimental and control kidneys for glomerular filtration rate, urine output, sodium and water excretion, renin activity, angiotensin II levels, plasmatic PGE2 levels, in group A as well as in group B. We conclude that portal blood of dogs contains vasoactive substances reducing renal blood flow; their action is mediated neither by the renin-angiotensin system nor by changes in renal PGE2 production. The complete abolition of this effect by Polymyxin suggests that these substances may be endotoxins.
N Bourgeois; C Reuse; M Gelin; M Buset; D Goldschmidt; V Ninane; M Quenon; J M Boeynaems; M Starkoukine; M Adler
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  411     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-05-13     Completed Date:  1988-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Service Médico-Chirurgical de Gastroentérologie, Institut de Recherches Interdisciplinaires, Hôpital Erasme.
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MeSH Terms
Glomerular Filtration Rate
Kidney / physiology*
Polymyxin B / pharmacology
Portal System*
Prostaglandins E / blood
Renal Circulation* / drug effects
Renin-Angiotensin System
Reg. No./Substance:
0/Prostaglandins E; 1404-26-8/Polymyxin B; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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