| Vasoconstriction of the basilar artery in rabbits: the vasoconstrictor activity of blood, CSF and blood-CSF mixtures incubated for varying periods of time. | |
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MedLine Citation:
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PMID: 3696355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After subarachnoid haemorrhage, the amount of blood in the subarachnoid space and the time elapsed since the haemorrhage seem important factors in predicting the occurrence of vasospasm. In this experiment we studied the responses of the rabbit basilar artery to acute topical application of samples of human cerebrospinal fluid (CSF), mixtures of blood and CSF incubated at 37 degrees C for 0 to 12 days. The degree and the duration of the vasoconstriction depended on the time of incubation and on the concentration of blood in the samples. Samples incubated for five and seven days caused severe and long-lasting vasoconstrictions. Samples incubated for 0, 1, 3, 8, 10 and 12 days caused slight or moderate and short-lasting vasoconstriction. Samples incubated for 5, 7, 8, and 10 days showed a linear relationship between the concentration of blood and the degree of constriction up to the blood-CSF ratio of 0.6 to 1 (blood content of 37.5%); further increases of blood concentration did not cause further vasoconstriction. This phenomenon may be related to the saturation of arterial receptors. The course of the vasoconstriction using samples with different blood concentrations suggests the existence of more vasoactive substances. This work seems to confirm the importance of blood concentration in the CSF and of time as factors governing the development of vasospasm. |
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Authors:
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E Fernandez; G Maira; R Pallini; A Puca |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurochirurgia Volume: 30 ISSN: 0028-3819 ISO Abbreviation: Neurochirurgia (Stuttg) Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1988-02-05 Completed Date: 1988-02-05 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0400774 Medline TA: Neurochirurgia (Stuttg) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 168-71 Citation Subset: IM |
Affiliation:
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Istituto di Neurochirurgia, Università Cattolica, Roma, Italia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basilar Artery / physiopathology* Blood-Brain Barrier* Intracranial Pressure Ischemic Attack, Transient / physiopathology* Male Prognosis Rabbits Subarachnoid Hemorrhage / physiopathology* Vasoconstriction* Vasoconstrictor Agents / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents |
| Comments/Corrections | |
Erratum In:
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Neurochirurgia (Stuttg) 1988 Mar;31(2):77 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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