| Vasoactive peptides and hypertension: role of angiotensin converting enzyme. | |
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MedLine Citation:
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PMID: 6266379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin converting enzyme plays a key role in the hormonal regulation of blood pressure. It is responsible for the production of the vasoconstrictor hormonal peptide angiotensin II as well as the destruction of the vasodilator peptide bradykinin. Recently, orally active specific inhibitors of angiotensin converting enzyme have become available. Captopril (SQ14225) blocks angiotensin I and potentiates bradykinin effects in vitro and in vivo. In man it leads to a fall in endogenous plasma angiotensin II, a rise in blood angiotensin I and renin, but no change in blood bradykinin can be detected. In sodium deplete normal subjects it lowers the blood pressure, but in sodium replete subjects it is without effect. Similarly, it will acutely lower blood pressure in renovascular and accelerated hypertension but not in essential hypertension. The acute hypotensive effect of captopril may therefore be due to inhibition of the renin-angiotensin system. However, in the long term, it is effective in lowering the blood pressure in patients with essential hypertension, especially when combined with a diuretic. This suggests that the long-term hypotensive effect differs from the short term effect, and involves mechanisms other than inhibition of the renin-angiotensin system. This may include local effects on blood vessels and the kidney and the kallikrein-kinin system. |
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Authors:
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C I Johnston; R Iansek; J A Millar; B P McGrath; P G Matthews |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Australian and New Zealand journal of medicine Volume: 11 ISSN: 0004-8291 ISO Abbreviation: Aust N Z J Med Publication Date: 1981 |
Date Detail:
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Created Date: 1981-09-22 Completed Date: 1981-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1264322 Medline TA: Aust N Z J Med Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 59-63 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin I
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blood Angiotensin II / blood* Angiotensin-Converting Enzyme Inhibitors Animals Bradykinin / blood* Captopril / pharmacology, therapeutic use Humans Hypertension / blood*, drug therapy Hypertension, Renovascular / drug therapy Peptidyl-Dipeptidase A / blood* Renin / blood |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 11128-99-7/Angiotensin II; 58-82-2/Bradykinin; 62571-86-2/Captopril; 9041-90-1/Angiotensin I; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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