| Vasoactive intracavernous pharmacotherapy for the treatment of erectile impotence in men with spinal cord injury. | |
| | |
MedLine Citation:
|
PMID: 2442418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A total of 66 spinal cord injury patients with erectile dysfunction entered a protocol of penile intracavernous pharmacotherapy with papaverine hydrochloride (30 mg. per ml.) or a combination of papaverine (25 mg. per ml.) and phentolamine mesylate (0.83 mg. per ml.) in an attempt to restore erectile function. Of the patients 52 completed the protocol and all achieved transient functional penile erections after administration of the drug. Of the 52 responders 71 per cent currently practice self-injection as a method to restore erectile function. Sustained erections that required irrigation of the cavernous bodies with alpha-adrenergic agents developed in 4 patients and 1 suffered localized intracorporeal induration. If the long-term followup shows that complications remain relatively minor, undoubtedly vasoactive intracavernous pharmacotherapy will have a major role in the restoration of erectile function in the motivated man with spinal cord injury. However, in view of the unknown long-term effects and potential dangers of this approach it is important that patients adhere to a strict drug injection protocol under the supervision of qualified urologists who are familiar with the potential risks and complications. |
| | |
Authors:
|
A A Sidi; J S Cameron; D D Dykstra; Y Reinberg; P H Lange |
Related Documents
:
|
8476168 - Teflon injection: pointers and pitfalls. 15217668 - Paradoxical vocal cord motion: an often misdiagnosed cause of postoperative stridor. 17297368 - A novel minimally invasive technique for spinal cord untethering. 16288188 - Adult syringomielia. classification, pathogenesis and therapeutic approaches. 19501418 - Trends in blunt laryngotracheal trauma in children. 15116608 - The mini-incision approach to total hip arthroplasty. |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: The Journal of urology Volume: 138 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1987 Sep |
Date Detail:
|
Created Date: 1987-10-05 Completed Date: 1987-10-05 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 539-42 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Clinical Trials as Topic Drug Combinations Erectile Dysfunction / drug therapy*, etiology Follow-Up Studies Humans Male Middle Aged Papaverine / therapeutic use* Penile Erection / drug effects* Phentolamine / analogs & derivatives*, therapeutic use Self Administration Spinal Cord Injuries / complications* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Drug Combinations; 50-60-2/Phentolamine; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Successful therapy of interstitial cystitis with pentosanpolysulfate.
Next Document: The effect of some urinary stone inhibitors on membrane interaction potentials of stone crystals.