Document Detail


Vasoactive intracavernous pharmacotherapy for the treatment of erectile impotence in men with spinal cord injury.
MedLine Citation:
PMID:  2442418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 66 spinal cord injury patients with erectile dysfunction entered a protocol of penile intracavernous pharmacotherapy with papaverine hydrochloride (30 mg. per ml.) or a combination of papaverine (25 mg. per ml.) and phentolamine mesylate (0.83 mg. per ml.) in an attempt to restore erectile function. Of the patients 52 completed the protocol and all achieved transient functional penile erections after administration of the drug. Of the 52 responders 71 per cent currently practice self-injection as a method to restore erectile function. Sustained erections that required irrigation of the cavernous bodies with alpha-adrenergic agents developed in 4 patients and 1 suffered localized intracorporeal induration. If the long-term followup shows that complications remain relatively minor, undoubtedly vasoactive intracavernous pharmacotherapy will have a major role in the restoration of erectile function in the motivated man with spinal cord injury. However, in view of the unknown long-term effects and potential dangers of this approach it is important that patients adhere to a strict drug injection protocol under the supervision of qualified urologists who are familiar with the potential risks and complications.
Authors:
A A Sidi; J S Cameron; D D Dykstra; Y Reinberg; P H Lange
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  138     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-05     Completed Date:  1987-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  539-42     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Clinical Trials as Topic
Drug Combinations
Erectile Dysfunction / drug therapy*,  etiology
Follow-Up Studies
Humans
Male
Middle Aged
Papaverine / therapeutic use*
Penile Erection / drug effects*
Phentolamine / analogs & derivatives*,  therapeutic use
Self Administration
Spinal Cord Injuries / complications*
Time Factors
Chemical
Reg. No./Substance:
0/Drug Combinations; 50-60-2/Phentolamine; 58-74-2/Papaverine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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