Document Detail

Vasoactive intestinal polypeptide-producing ganglioneuromatosis involving the entire colon and rectum.
MedLine Citation:
PMID:  19302839     Owner:  NLM     Status:  MEDLINE    
Vasoactive intestinal polypeptide (VIP) is known to cause the watery diarrhea, hypokalemia, and achlorhydria syndrome. A 14-year-old girl was admitted with a 4-year history of persistent uncontrollable diarrhea and hypokalemia. Computed tomographic evaluation of the neck, chest, and abdomen were normal. Numerous polyps covering the entire colon and rectum were noted on colonoscopy. The serum VIP level was 143 pg/mL. The patient underwent a total proctocolectomy with an ileal-J-pouch. The pathologic examination revealed ganglioneuromatosis. Postoperatively, the symptoms resolved, and the serum VIP level fell to lower than 5 pg/mL. This is an unusual case of the watery diarrhea, hypokalemia, and achlorhydria syndrome caused by ganglioneuromatosis of the entire colon and rectum.
Suk-Bae Moon; Kwi-Won Park; Sung-Eun Jung; Seong-Cheol Lee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  44     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e19-21     Citation Subset:  IM    
Department of Pediatric Surgery, Seoul National University Children's Hospital, Seoul 110-744, Korea.
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MeSH Terms
Colonic Neoplasms / metabolism*,  surgery
Colonic Pouches
Ganglioneuroma / metabolism*,  surgery
Proctocolectomy, Restorative
Rectal Neoplasms / metabolism*
Vasoactive Intestinal Peptide / blood,  metabolism*
Reg. No./Substance:
37221-79-7/Vasoactive Intestinal Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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