| Vasoactive intestinal polypeptide increases whole pancreatic blood flow but does not affect islet blood flow in the rat. | |
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MedLine Citation:
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PMID: 7949220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the effects of vasoactive intestinal peptide (VIP) on whole pancreatic blood flow and islet blood flow in the rat, anaesthetized adult rats were injected intravenously for 90 s with VIP (500 ng/kg body weight). Immediately after the injection, the whole pancreatic and islet blood flows were measured with a microsphere technique. VIP markedly increased the former but did not affect the latter. Thus, the fraction of the whole pancreatic blood flow diverted through the islets was decreased. In separate experiments, the effects of VIP on the blood glucose and serum insulin concentrations of anaesthetized animals were investigated. VIP caused an acute increase (after 2 min) in the latter, but did not affect the former. It is concluded that VIP exerts its blood flow stimulatory properties only on the exocrine pancreas, and that it may increase the serum insulin concentrations without an associated change in islet blood perfusion. |
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Authors:
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L Jansson |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta diabetologica Volume: 31 ISSN: 0940-5429 ISO Abbreviation: Acta Diabetol Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-12-02 Completed Date: 1994-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 103-6 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / drug effects, metabolism Blood Pressure / drug effects Insulin / blood, secretion* Islets of Langerhans / blood supply* Male Microspheres Pancreas / blood supply* Rats Rats, Sprague-Dawley Reference Values Regional Blood Flow / drug effects Time Factors Vasoactive Intestinal Peptide / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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