Document Detail

Vasoactive intestinal polypeptide (VIP) inhibits prostaglandin-F2 alpha-induced activity of the rabbit myometrium.
MedLine Citation:
PMID:  7384549     Owner:  NLM     Status:  MEDLINE    
Seven female rabbits ahd myometrial autografts transplanted into ear-chambers. The electrical activity of the graft was recorded and mechanical activity observed. Vasoactive intestinal polypeptide (VIP) dose-dependently inhibited myometrial activity induced by prostaglandin-F2 alpha. This evidence and the occurrence of "VIPergic" nerve fibres, which seem to innervate the myometrial cells, suggest that VIP may play a physiological role in the local control of the myometrial activity.
B Ottesen; G Wagner; J Fahrenkrug
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  19     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  427-35     Citation Subset:  IM    
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MeSH Terms
Gastrointestinal Hormones / pharmacology*
Myometrium / innervation,  transplantation
Nerve Fibers / drug effects
Prostaglandins F / antagonists & inhibitors*
Transplantation, Autologous
Uterine Contraction / drug effects*
Vasoactive Intestinal Peptide / pharmacology*,  physiology
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Prostaglandins F; 37221-79-7/Vasoactive Intestinal Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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